Decrease in serum matrix metalloproteinase-9 and matrix metalloproteinase-3 levels in Zucker fa/fa obese rats after treatment with swertiamarin.
Decrease in serum matrix metalloproteinase-9 and matrix metalloproteinase-3 levels in Zucker fa/fa obese rats after treatment with swertiamarin.
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发表时间：
2012
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通讯作者：
Hanumesh Vaidya;S. Giri;M. Jain;R. Goyal
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作者：
Hanumesh Vaidya;S. Giri;M. Jain;R. Goyal
糖尿病包括一组与心血管并发症相关的慢性代谢疾病，如动脉粥样硬化、心肌病和肾病。在本研究中，作者研究了苦马豆素对Zucker fa/fa大鼠糖尿病及其相关心血管并发症的益处。每组6只雄性Zucker fa/fa大鼠，分别给予马钱子素(75 mg/kg/d)或吡格列酮(30 mg/kg/d)灌胃28d。采集了血液样本，并对几个参数进行了评估。在未经治疗的Zucker fa/fa大鼠中，发现血糖、甘油三酯、非酯化游离脂肪酸和胆固醇水平升高。未经治疗的Zucker fa/fa大鼠血清基质金属蛋白酶(MMP9)和MMP3水平也显著升高。与未治疗的大鼠相比，给予苦马豆素治疗的大鼠显著降低血糖、甘油三酯、非酯化游离脂肪酸和胆固醇水平，并降低血清基质金属蛋白酶-9和基质金属蛋白酶-3水平(P<；0.05)。与未治疗的Zucker fa/fa大鼠相比，Swertiamarin还能显著降低血清尿素水平(P<；0.05)。总体而言，数据表明，苦马豆素对糖尿病引起的心血管并发症，如动脉粥样硬化和肾病，产生了有益的影响。马钱子素诱导的血清基质金属蛋白酶-9和基质金属蛋白酶-3水平的降低可能是改善这些并发症的机制之一。
Diabetes mellitus encompasses a group of chronic metabolic conditions associated with cardiovascular complications such as atherosclerosis, cardiomyopathy and nephropathy. In the present study, the authors investigated the beneficial effects of swertiamarin in diabetes and its associated cardiovascular complications in Zucker fa/fa rats. Six male Zucker fa/fa rats in each group were treated for 28 days with swertiamarin (75 mg/kg/day, intraperitoneally) or pioglitazone (30 mg/kg orally). Blood samples were collected and evaluated for several parameters. Elevated serum glucose, triglyceride, nonesterified free-fatty acid and cholesterol levels were found in untreated Zucker fa/fa rats. Serum matrix metalloproteinase (MMP)-9 and MMP-3 levels were also found to be significantly higher in untreated Zucker fa/fa rats. Treatment with swertiamarin significantly (P<0.05) reduced serum glucose, triglyceride, nonesterified free-fatty acid and cholesterol levels, and also reduced serum MMP-9 and MMP-3 levels compared with untreated rats. Swertiamarin also significantly (P<0.05) decreased serum levels of urea compared with untreated Zucker fa/fa rats. Overall, the data suggest that swertiamarin produced beneficial effects with respect to diabetes-induced cardiovascular complications such as atherosclerosis and nephropathy. A swertiamarin-induced decrease in serum MMP-9 and MMP-3 levels is one of the possible mechanisms responsible for improvement of these complications.