Thyroid volume measurement in thyrotoxic patients: comparison between ultrasonography and iodine-124 positron emission tomography
Thyroid volume measurement in thyrotoxic patients: comparison between ultrasonography and iodine-124 positron emission tomography
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DOI：
10.1007/s002590050176
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发表时间：
1997-12-01
期刊：
影响因子：
--
通讯作者：
Harmer, CL
中科院分区：
文献类型：
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作者：
Crawford, DC;Flower, MA;Harmer, CL
本文旨在比较超声（US）评估甲状腺体积与正电子发射断层扫描（PET）获得的甲状腺体积，在计划进行适应性放射性碘治疗的患者中，其中规定功能PET体积为50戈伊。首先进行了一项初步研究，以确定US评估甲状腺体积的最佳方法，然后对15例患者进行了17次甲状腺体积的超声和PET对比测量（2名男性和13名女性，年龄28-73岁），该比较显示在正常大小和增大的甲状腺（n=13）中，功能PET与解剖US体积的比率约为2：3，然而，使用相同的椭球体模型，PET和解剖体积的US评估在测量误差内一致。由于结节的存在和放射性碘的不均匀分布，功能PET体积和解剖US体积通常不相等。如果高分辨率发射断层扫描（如FET）不可用，本文中提供的比较数据可用于从US体积推导功能体积，以计算接受放射性碘治疗的甲亢患者的功能甲状腺剂量。
The aim of this paper was to compare ultrasound (US) assessment of thyroid volume with that obtained by positron emission tomography (PET), in patients scheduled for adaptive radioiodine therapy, in which 50 Gy was prescribed to the functional PET volume, Firstly a pilot study was performed to ascertain the optimum method for US assessment of thyroid volume, Then 17 comparative measurements of thyroid volume by US and PET were made on 15 patients (two male and thirteen female, ages 28-73 years) with suspected Graves' disease, This comparison showed that in normal sized and enlarged thyroid glands (n=13), the ratio of functional PET to anatomical US volume was approximately 2:3, However, using the same ellipsoid model, PET and US assessment of anatomical volume agreed within the measurement errors. Owing to the presence of nodules and non-uniform distribution of radioiodine, the functional PET volume and anatomical US volume are often not equivalent. If high-resolution emission tomography (e.g. FET) is unavailable, the comparative data presented in this paper could be used to derive the functional volume from the US volume for calculating functional thyroid dose in hyperthyroid patients undergoing radioiodine therapy.