Hollow Porous Carbon Coated FeS2-Based Nanocatalysts for Multimodal Imaging-Guided Photothermal, Starvation, and Triple-Enhanced Chemodynamic Therapy of Cancer
Hollow Porous Carbon Coated FeS2-Based Nanocatalysts for Multimodal Imaging-Guided Photothermal, Starvation, and Triple-Enhanced Chemodynamic Therapy of Cancer
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DOI：
10.1021/acsami.0c00170
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发表时间：
2020-03-04
影响因子：
9.5
通讯作者：
Li, Ao
中科院分区：
文献类型：
--
作者：
Wu, Fan;Zhang, Qicheng;Li, Ao
特定的化学反应只发生在肿瘤区域，并产生丰富的特殊化学物质，在原位引发一系列生物学和病理学效应，使肿瘤特异性治疗效果能够治疗癌症，而不会对正常细胞或器官造成严重的副作用。化学动力学疗法（chemodynamic therapy，CDT）是近年来兴起的一种肿瘤治疗手段，它通过局部芬顿反应诱导肿瘤细胞死亡。然而，肿瘤治疗效果受到化学反应效率的限制，并且严重依赖于催化剂。在这里，我们构建了空心多孔碳包覆FeS2（HPFeS2@C）为基础的纳米催化剂的三重增强CDT。将单宁酸包覆于HPFeS2@C中，使Fe3+还原为Fe2+，具有较好的催化活性，促进了芬顿反应的进行。纳米催化剂中的葡萄糖氧化酶（GOx）可以消耗肿瘤微环境中的葡萄糖，同时原位产生H2O2，提高芬顿反应效率。同时，葡萄糖的消耗可能导致饥饿疗法。HPFeS2@C的光热效应可以产生热量，进一步加速了芬顿过程，实现了光热/饥饿/CDT协同效应。通过多模态磁共振、超声和光声成像研究纳米颗粒的生物分布。这些纳米催化剂能够高度催化芬顿反应，为纳米催化肿瘤治疗提供了一个良好的范例。
Specific chemical reactions only happen in the tumor region and produce abundant special chemicals to in situ trigger a train of biological and pathological effects that may enable tumor-specific curative effects to treat cancer without causing serious side effects on normal cells or organs. Chemodynamic therapy (CDT) is a rising tactic for cancer therapy, which induces cancer cell death via a localized Fenton reaction. However, the tumor therapeutic effect is limited by the efficiency of the chemical reaction and relies heavily on the catalyst. Here, we constructed hollow porous carbon coated FeS2(HPFeS2@C)-based nanocatalysts for triple-enhanced CDT. Tannic acid was encapsulated in HPFeS2@C for reducing Fe3+ to Fe2+, which had a better catalytic activity to accelerate the Fenton reaction. Afterward, glucose oxidase (GOx) in nanocatalysts could consume glucose in the tumor microenvironment and in situ synchronously produce H2O2, which could improve Fenton reaction efficiency. Meanwhile, the consumption of glucose could lead to the starvation therapy. The photothermal effects of HPFeS2@C could generate heat, which further sped up the Fenton process and implemented synergetic photothermal therapy/starvation therapy/CDT. The biodistribution of nanoparticles was investigated by multimodal magnetic resonance, ultrasound, and photoacoustic imaging. These nanocatalysts could trigger the catalytic Fenton reaction at a high degree, which might provide a good paradigm for nanocatalytic tumor therapy.