Hepatocellular Carcinoma in Women: Probable Lack of Etiologic Association with Oral Contraceptive Steroids
Hepatocellular Carcinoma in Women: Probable Lack of Etiologic Association with Oral Contraceptive Steroids
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女性肝细胞癌：可能与口服避孕类固醇缺乏病因关联
作者：
Z. Goodman;K. Ishak
为了研究口服避孕药类固醇（CS）与肝细胞癌（HCC）之间的关系，我们回顾了1953年至1980年间收集的128例女性HCC病例。年龄在40岁以下的48例，其中13例（27%）使用了CS。然而，62%与CS相关的HCC和58%未使用CS的40岁以下女性HCC在组织学上被归类为“纤维板层”癌。这种亚型HCC主要发生在年轻人中，男性和女性都有。年轻女性中HCC的明显增加可以解释为该年龄组中纤维板层癌的存在，而与CS的明显关联可能是巧合。
To investigate the possibility of an association between oral contraceptive steroids (CS) and hepatocellular carcinoma (HCC), we reviewed 128 cases of HCC in women collected between 1953 and 1980. There were 48 cases under the age of 40, and 13 of these (27%) had used CS. However, 62% of HCC associated with CS and 58% of HCC in women under 40 not using CS were classified histologically as “fibrolamellar” carcinoma. This subtype of HCC occurs predominantly in young people, both male and female. The apparent increase in HCC in young women can be explained by the presence of cases of fibrolamellar carcinoma in this age group, and the apparent association with CS is probably coincidental.