Mechanism of function of viral channel proteins and implications for drug development.
Mechanism of function of viral channel proteins and implications for drug development.
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DOI：
10.1016/b978-0-12-394305-7.00006-9
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发表时间：
2012
影响因子：
--
通讯作者：
Chen CP
中科院分区：
文献类型：
--
作者：
Fischer WB;Wang YT;Schindler C;Chen CP
病毒通道形成蛋白包括一类病毒蛋白，类似于它们的宿主伴侣，被制造来改变跨脂质膜的电化学或底物梯度。这些蛋白质在病毒细胞生命周期的所有阶段都有活性。越来越多的蛋白质被鉴定为通道蛋白，但它们中的大多数在病毒生命周期中的确切作用尚不清楚。本文综述了这些蛋白质的概况，重点介绍了那些具有可用结构信息的蛋白质。介绍了一种将病毒通道蛋白的跨膜结构域与宿主通道和毒素的跨膜结构域进行比对的概念，以便从潜在的序列身份中深入了解病毒蛋白的功能机制。总结了迄今为止针对这些蛋白质的药物研究，并讨论了它们在体内的作用方式。
Viral channel-forming proteins comprise a class of viral proteins which, similar to their host companions, are made to alter electrochemical or substrate gradients across lipid membranes. These proteins are active during all stages of the cellular life cycle of viruses. An increasing number of proteins are identified as channel proteins, but the precise role in the viral life cycle is yet unknown for the majority of them. This review presents an overview about these proteins with an emphasis on those with available structural information. A concept is introduced which aligns the transmembrane domains of viral channel proteins with those of host channels and toxins to give insights into the mechanism of function of the viral proteins from potential sequence identities. A summary of to date investigations on drugs targeting these proteins is given and discussed in respect of their mode of action in vivo.