[18F]DPA-714, [18F]PBR111 and [18F]FEDAA1106-Selective radioligands for imaging TSPO 18 kDa with PET: Automated radiosynthesis on a TRACERLAb FX-FN synthesizer and quality controls
[18F]DPA-714, [18F]PBR111 and [18F]FEDAA1106-Selective radioligands for imaging TSPO 18 kDa with PET: Automated radiosynthesis on a TRACERLAb FX-FN synthesizer and quality controls
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DOI：
10.1016/j.apradiso.2011.10.015
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发表时间：
2012-03-01
影响因子：
1.6
通讯作者：
Dolle, Frederic
中科院分区：
文献类型：
--
作者：
Kuhnast, Bertrand;Damont, Annelaure;Dolle, Frederic
PET对TSPO 18 kDa的成像越来越被认为是许多疾病中炎症的相关生物标志物。用于TSPO 18 kDa的新放射性示踪剂的开发在过去几年中已经加速，并且今天的挑战是使大量的这种放射性示踪剂符合GMP标准以用于人类。我们在本技术说明中介绍了使用TRACERlab FX-FN合成仪自动生产[F-18]DPA-714、[F-18] PBR 111和[F-18] FEDAA 1106，这三种有前途的放射性示踪剂用于Tspo 18 kDa成像。本记录还包括用于[F-18]DPA-714临床生产确认的验证批次的质量控制数据。(C)2011爱思唯尔有限公司保留所有权利。
Imaging of TSPO 18 kDa with PET is more and more considered as a relevant biomarker of inflammation in numerous diseases. Development of new radiotracers for TSPO 18 kDa has seen acceleration in the last years and the challenge today is to make available large amounts of such a radiotracer in compliance with GMP standards for application in humans. We present in this technical note automated productions of [F-18]DPA-714, [F-18]PBR111 and [F-18]FEDAA1106, three promising radiotracers for Tspo 18 kDa imaging, using a TRACERlab FX-FN synthesizer. This note also includes the quality control data of the validation batches for the manufacturing qualification of clinical production of [F-18]DPA-714. (C) 2011 Elsevier Ltd. All rights reserved.