Rapidly evolving genes of Drosophila:: Differing levels of selective pressure in testis, ovary, and head tissues between sibling
Rapidly evolving genes of Drosophila:: Differing levels of selective pressure in testis, ovary, and head tissues between sibling
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DOI：
10.1093/molbev/msi175
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发表时间：
2005-09-01
影响因子：
10.7
通讯作者：
Singh, RS
中科院分区：
文献类型：
--
作者：
Jagadeeshan, S;Singh, RS
对快速进化的性和生殖相关基因的研究有望揭示物种形成过程和物种分化的重要信息。我们筛选了睾丸、卵巢和头部组织，以鉴定和表征近亲物种之间的快速进化基因（REGs）。结果表明，生殖和非生殖组织中基因表达的进化模式存在差异。(1)果蝇基因组中REGs的分布存在差异，大多数REGs位于睾丸，其次是卵巢，最后是头部。(2)序列分析表明，不同的选择压力驱动着有性组织和非有性组织中基因表达的快速进化。从我们的数据来看，睾丸REGs相对于卵巢和头部的转录本平均产生更高的非同义替换率，表明男性生殖系统面临更大的选择压力。(3)我们在睾丸、卵巢和头部组织中发现了REGs，这些REGs显示出在正选择下进化的证据。识别快速进化的性基因对于详细研究雌性的隐性选择、性冲突和雄性的快速进化具有重要意义，并且与我们对物种分化和物种形成过程的理解有关。
Investigations of rapidly evolving sex- and reproduction-related genes are expected to reveal important information about the process of speciation and species divergence. We screened testis, ovary, and head tissues to identify and characterize rapidly evolving genes (REGs) between closely related species. The results show differential patterns of evolution of genes expressed in reproductive and nonreproductive tissues. (1) There is a differential distribution of REGs in the Drosophila genome, with most REGs localized in the testis, followed by ovary, and then head. (2) Sequence analysis indicates that differential selective pressures are driving the rapid evolution of genes expressed in sex and nonsex tissues. Testis REGs from our data, on average, yielded higher rates of nonsynonymous substitutions relative to transcripts in ovary and head, indicating stronger selective pressures on the male reproductive system. (3) We identified REGs in the testis, ovary, as well as in head tissue that show evidence of evolving under positive selection. Identification of rapidly evolving sex genes is important for detailed investigations of cryptic female choice, sexual conflict, and faster male evolution and is pertinent to our understanding of the process of species divergence and speciation.