Mechanisms and principles of N-linked protein glycosylation
Mechanisms and principles of N-linked protein glycosylation
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DOI：
10.1016/j.sbi.2011.08.005
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发表时间：
2011-10-01
影响因子：
6.8
通讯作者：
Aebi, Markus
中科院分区：
文献类型：
--
作者：
Schwarz, Flavio;Aebi, Markus
n -链糖基化是一种存在于生命所有领域的蛋白质修饰系统，其特点是在不同物种中发现的n -链聚糖具有高度的结构多样性，并且大量的蛋白质被糖基化。基于结构、功能和系统发育的方法，本文讨论了这种独特的通用蛋白质修饰系统的高度保守过程。
N-linked glycosylation, a protein modification system present in all domains of life, is characterized by a high structural diversity of N-linked glycans found among different species and by a large number of proteins that are glycosylated. Based on structural, functional, and phylogenetic approaches, this review discusses the highly conserved processes that are at the basis of this unique general protein modification system.