Hes1 and Hes5 regulate the development of the cranial and spinal nerve systems
Hes1 and Hes5 regulate the development of the cranial and spinal nerve systems
复制标题
DOI：
10.1159/000090756
复制
发表时间：
2006-01-01
影响因子：
2.9
通讯作者：
Kageyama, R
中科院分区：
文献类型：
--
作者：
Hatakeyama, J;Sakamoto, S;Kageyama, R
基本的螺旋-环-螺旋基因 Hes1 和 Hes5（已知的 Notch 效应子）调节神经干细胞的维持和中枢神经系统 (CNS) 的发育。在Hes1和Hes5缺失的情况下，中枢神经系统的大小、形状和细胞结构严重紊乱，但周围神经系统的发育仍有待分析。在这里，我们在 Hes1 中发现了这一点； Hes5双突变小鼠，脑神经和脊神经系统也严重紊乱。在这些突变小鼠中，从中脑神经元到三叉神经节（V）的轴突投射变得异常，舌咽神经（IX）和迷走神经（X）的近端部分融合。舌下神经（XII）的形成也很差。此外，背根神经节与脊髓融合，脊神经的背根和腹根多节段缺失。这些结果表明Hes1和Hes5在颅神经和脊髓神经系统的形成中发挥重要作用。
The basic helix-loop-helix genes Hes1 and Hes5, known Notch effectors, regulate the maintenance of neural stem cells and the development of the central nervous system (CNS). In the absence of Hes1 and Hes5, the size, shape and cytoarchitecture of the CNS are severely disorganized, but the development of the peripheral nervous system remains to be analyzed. Here, we found that in Hes1; Hes5 double-mutant mice, the cranial and spinal nerve systems are also severely disorganized. In these mutant mice, axonal projections from the mesencephalic neurons to the trigeminal (V) ganglion become aberrant and the proximal parts of the glossopharyngeal (IX) and vagus (X) nerves are fused. The hypoglossal (XII) nerve is also formed poorly. Furthermore, the dorsal root ganglia are fused with the spinal cord, and the dorsal and ventral roots of the spinal nerves are lacking in many segments. These results indicate that Hes1 and Hes5 play an important role in the formation of the cranial and spinal nerve systems.