Outcome of mammography in women with large breasts
Outcome of mammography in women with large breasts
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DOI：
10.1016/j.breast.2011.12.001
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发表时间：
2012-08-01
期刊：
影响因子：
3.9
通讯作者：
Wylie, Elizabeth
中科院分区：
文献类型：
--
作者：
Gayde, Ceyda;Goolam, Ismail;Wylie, Elizabeth
乳腺X线摄影已被确立为早期发现乳腺癌的有效筛查工具。肥胖可能导致乳房增大，并与乳腺癌发病率增加有关。由于乳房较大的女性可能容易患上癌症，因此乳房X光检查是这些女性的适当检查。本研究调查的敏感性和特异性的乳房较大的妇女在人口screeningprogram.Method：数据来自848 648个合格的筛查事件的妇女年龄在40岁以上。在这些事件中，有758860例符合研究条件，其中7.2%（54879例筛查）被认为有乳房肥大。大乳房定义为在乳房X线摄影过程中至少使用一个大暗盒的乳房。那些每个屏幕只有四个标准暗盒的妇女被归类为具有平均大小的乳房（703981个屏幕，92.8%）。比较了使用标准尺寸卡匣和大卡匣检查的女性的癌症检出率、间隔癌症率（假阴性）和评估召回率。机会校正措施的灵敏度和特异性和95%的置信区间（Cl）计算妇女和没有大breasts.Results：研究发现，乳房X线摄影的灵敏度和特异性较大的乳房妇女。还发现，在合并人群中，乳房较大的女性乳腺癌的发病率较高（大胸女性为每100，000人中73.1人（95%CI 65.9-80.2），而其他女性为52.8人（95%CI 51.1-54.5）和每个特定年龄组。这项研究证实了乳房X线筛查对乳房肥大妇女的适当性。(c)2011爱思唯尔有限公司版权所有。
Mammography has been established as an effective screening tool for the early detection of breast cancer. Obesity may lead to increased breast size and has been linked to increased rates of breast cancer. As women with larger breasts may be predisposed to developing cancer, it is important that mammography is an appropriate test in these women. This study investigated the sensitivity and specificity of mammography in women with larger breasts in a population screening program.Method: Data was obtained from 848 648 eligible screening episodes of women aged over 40. Of these episodes, 758 860 were eligible for the study, with 7.2% (54 879 screens) deemed to have large breasts. Large breasts were defined as those for whom at least one large cassette was used in the mammographic process. Those women having only four standard cassettes per screen were classified as having average size breasts (703 981 screens, 92.8%). Cancer detection rates, interval cancer rates (false negatives) and recall to assessment rates were compared for women examined on standard sized cassettes versus large cassettes. Chance corrected measures of sensitivity and specificity and 95% confidence intervals (Cl) were calculated for women with and without large breasts.Results: The study found that the sensitivity and specificity of mammography was greater for larger breasted woman. The incidence of breast cancer was also found to be higher in woman with larger breasts in the combined population (73.1 per 100,000(95% CI 65.9-80.2) in large breasted women versus 52.8 (95% CI 51.1-54.5) in other women) and in each of the specific age groups. This study confirms the appropriateness of mammographic screening for women with large breasts. (c) 2011 Elsevier Ltd. All rights reserved.