Two new 5,6-epoxysterols from calcareous marine sponge Leucetta chagosensis
Two new 5,6-epoxysterols from calcareous marine sponge Leucetta chagosensis
复制标题
来自钙质海洋海绵 Leucetta chagosensis 的两种新 5,6-环氧甾醇。
DOI：
10.1080/14786419.2018.1513510
复制
发表时间：
2019-09-29
影响因子：
2.2
通讯作者：
Lin, Hou-Wen
中科院分区：
文献类型：
--
作者：
Tang, Wei-Zhuo;Yang, Zhong-Zhen;Lin, Hou-Wen
对采自中国南海的查哥斯白海绵（Leucetta chagosensis）的CH_2Cl_2萃取物进行化学研究，得到两个新的5，6-环氧甾醇：5 α，6 α-环氧胆甾-8（14），22（E）-二烯-3 β，7 α-二醇（1）和（24 R）-24-乙基-5 α，6 α-环氧胆甾-8（14），22（E）-二烯-3 β，7 α-二醇（2）沿着10种已知的相关类固醇类似物（3-12）。根据核磁共振波谱分析并与文献进行比较，确定了它们的结构。测试所有分离物对三种肿瘤细胞系的细胞毒性，仅已知化合物11和12分别对A549（IC 50：3.0和5.6 μ M）、PC 9（2.0和15.6 μ M）和MCF-7（9.4和11.8 μ M）细胞系显示出显著的细胞毒性活性。[图形]。
Chemical investigation on CH2Cl2 extract of the marine sponge Leucetta chagosensis, collected from the South China Sea, afforded two new 5,6-epoxysterols, 5 alpha,6 alpha-epoxycholesta-8(14),22(E)-diene-3 beta,7 alpha-diol (1) and (24R)-24-ethyl-5 alpha,6 alpha-epoxycholesta-8(14),22(E)-diene-3 beta,7 alpha-diol (2) along with ten known related steroid analogs (3-12). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparison with the literature. All isolates were tested for cytotoxicity against three tumor cell lines only known compounds 11 and 12 exhibited notable cytotoxic activity against A549 (IC50: 3.0 and 5.6 mu M), PC9 (2.0 and 15.6 mu M), and MCF-7 (9.4 and 11.8 mu M) cell lines, respectively.[GRAPHICS].