Acute liver dystrophy with thrombosis of hepatic veins: a fatal complication of dacarbazine treatment.
Acute liver dystrophy with thrombosis of hepatic veins: a fatal complication of dacarbazine treatment.
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急性肝营养不良伴肝静脉血栓形成：达卡巴嗪治疗的致命并发症。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
D. Wacker
中科院分区：
文献类型：
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作者：
W. Féaux de Lacroix;U. Runne;H. Hauk;K. Doepfmer;W. Groth;D. Wacker
在恶性黑色素瘤切除后用达卡巴嗪进行辅助单药化疗的过程中，在我们的四名患者中观察到致命的并发症。在治疗的第二个周期，由于大量肝坏死并发肝功能衰竭，肝静脉广泛血栓形成。我们的病人的临床和病理特征进行了比较，在八个已发表的情况下的结果。详细讨论了可能的发病机制，布-加综合征引起的过敏性血栓性静脉炎继发肝细胞坏死似乎是最有可能的。
In the course of adjuvant single-agent chemotherapy with dacarbazine after extirpation of malignant melanoma, a fatal complication was observed in four of our patients. During the second cycle of therapy liver failure due to massive hepatic necrosis supervened, with widespread thrombosis of liver veins. The clinical and pathologic features of our patients are compared with the findings in eight published cases. The possible pathogenesis is discussed in detail, and Budd-Chiari syndrome caused by an allergic thrombophlebitis with secondary liver cell necrosis seems to be most probable.