Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase -: a key enzyme in M-tuberculosis cell wall biosynthesis
Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase -: a key enzyme in M-tuberculosis cell wall biosynthesis
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DOI：
10.1039/b411554f
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发表时间：
2004-01-01
影响因子：
3.2
通讯作者：
Thomas, NR
中科院分区：
文献类型：
--
作者：
Cren, S;Gurcha, SS;Thomas, NR
Two iminosugars have been designed and synthesized as potential inhibitors of UDP-Galf transferase, an enzyme involved in Mycobacterium tuberculosis cell wall biosynthesis. The design is based on a proposed model of the transition state for the transferase reaction. One of the two racemic compounds is the first reported inhibitor of the target enzyme from M. smegmatis.
