Effects of two doses of methylphenidate on verbal information processing in hyperactive children.
Effects of two doses of methylphenidate on verbal information processing in hyperactive children.
复制标题
两种剂量的哌醋甲酯对多动儿童言语信息处理的影响。
DOI：
10.1097/00004714-198404020-00004
复制
发表时间：
1984
影响因子：
2.9
通讯作者：
Reus,V
中科院分区：
文献类型：
--
作者：
Peeke,S;Halliday,R;Callaway,E;Prael,R;Reus,V
：9名多动症儿童参加了三次会议。在每一个过程中，他们被给予三种药物（安慰剂，10毫克，或21毫克哌甲酯）在一个双盲交叉研究。给药后，他们接受了三项认知任务的测试。对于一项任务，结构，声学，或语义程度的编码的口头信息。然后测试对口头信息的记忆。10 mg剂量导致单词识别和回忆的整体改善。21 mg剂量未导致改善。提高的程度与词的编码程度无关。另外两项任务，学习单词列表和从简短的显示中视觉搜索字母，不受10或21 mg剂量的影响。结果表明，语言学习可以促进低剂量的哌醋甲酯，但剂量范围可能很窄。此外，某些个体对任何一种剂量都没有积极的反应。在讨论的结果，提出的可能性，哌甲酯诱导的促进可能仅限于某些类型的学习或某些方法评估检索的信息。
: Nine hyperactive children participated in three sessions. During each they were given one of three drugs (placebo, 10 mg, or 21 mg of methylphenidate) in a double-blind crossover study. Following drug administration they were tested on three cognitive tasks. For one task, structural, acoustic, or semantic degrees of encoding of verbal information were induced. Memory for the verbal information was then tested. The 10-mg dose resulted in overall improvement of word recognition and recall. The 21-mg dose did not result in improvement. Amount of improvement was not related to degree of encoding of words. Two other tasks, learning a list of words and visual search of letters from a briefly presented display, were not affected by either the 10-or 21-mg dose. The results indicate that verbal learning can be facilitated by a low dose of methylphenidate but that the dose range may be narrow. Also, certain individuals did not respond favorably to either dose. In discussing the results, the possibility is presented that methylphenidate-induced facilitation may be restricted to certain types of learning or certain methods of assessing retrieval of information.