Magnetic resonance imaging and other techniques in the diagnosis of multiple sclerosis.
Magnetic resonance imaging and other techniques in the diagnosis of multiple sclerosis.
复制标题
磁共振成像和其他技术在诊断多发性硬化症中的应用。
DOI：
10.1001/archneur.1985.04060080037013
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发表时间：
1985
影响因子：
--
通讯作者：
A. Price
中科院分区：
文献类型：
--
作者：
H. Kirshner;S. Tsai;V. Runge;A. Price
我们对35例多发性硬化症(MS)患者进行了磁共振成像(MRI)、脑脊液(CSF)分析、诱发电位检测和CT扫描。根据McAline等人、McDonald和Halliday标准，27例患者确诊为MS，3例可能为MS，5例可能为MS。所有患者均有MRI可发现的多发性脑白质病变，主要见于脑室周围，但也可见于大脑或小脑白质。根据病变的数目和大小判断，MRI异常的严重程度与CT扫描阳性的可能性相关，但与病程、残疾程度或阳性脑脊液寡克隆区带无关。磁共振成像成功显示了15名患者的脑干病变(CT扫描均未发现)。磁共振成像似乎是多发性硬化症病变的敏感指标，但临床评估将继续是诊断多发性硬化症的关键。
We evaluated 35 patients with multiple sclerosis (MS) by magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, evoked potential testing, and computed tomographic (CT) scanning. As classified by the McAlpine et al and McDonald and Halliday criteria, 27 patients had definite MS, three had probable MS, and five had possible MS. All of the patients had multiple white matter lesions detectable by MRI that were evident predominantly in the periventricular areas but also in the cerebral or cerebellar white matter. The severity of the MRI abnormality, as judged by the number and size of the lesions, correlated with the likelihood of a positive CT scan but not with the duration of disease, the degree of disability, or positive CSF oligoclonal banding. Magnetic resonance imaging successfully demonstrated brain-stem lesions in 15 patients (none were seen on CT scans). Magnetic resonance imaging seems to be a sensitive indicator of MS lesions, but clinical assessment will continue to be crucial to the diagnosis of MS.