THE EFFECT OF GENETIC AND ENVIRONMENTAL-FACTORS ON THE PREVALENCE OF ALLERGIC DISORDERS AT THE AGE OF 2 YEARS
THE EFFECT OF GENETIC AND ENVIRONMENTAL-FACTORS ON THE PREVALENCE OF ALLERGIC DISORDERS AT THE AGE OF 2 YEARS
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DOI：
10.1111/j.1365-2222.1993.tb03238.x
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发表时间：
1993-06-01
影响因子：
6.1
通讯作者：
HIDE, DW
中科院分区：
文献类型：
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作者：
ARSHAD, SH;STEVENS, M;HIDE, DW
在一项前瞻性跟踪研究中，确定了遗传和环境因素对儿童早期变态反应性疾病患病率的影响。获得了1174名2岁儿童的信息。275的人被认为患有过敏性疾病。患病率从鼻炎的3.2%到哮喘的10.9%不等。2岁时60名儿童皮肤点刺试验(SPT)阳性。采用多元Logistic回归分析，得到各因素的调整优势比(95%可信区间)。阳性家族史、男性、低出生体重、母亲吸烟和出生季节是哮喘的显著危险因素。对于湿疹来说，阳性家族史是唯一重要的危险因素。对于鼻炎，较低的社会经济群体和秋季出生有显著意义。男性和低出生体重儿对皮试阳性有显著影响。阳性家族史和低出生体重是任何过敏的重要危险因素。低出生体重也是皮肤测试对室内尘螨反应的一个重要风险。遗传和环境因素对出生后头两年的过敏性疾病的发展有深远的影响。
The effect of genetic and environmental factors on the prevalence of allergic disorders in early childhood was determined in a prospective follow-up study. Information was available on 1174 children at the age of 2 years. Two-hundred and seventy-five were considered to have an allergic disorder. The prevalence varied from 3.2% for rhinitis to 10.9% for asthma. At 2 years 60 children reacted positively on skin-prick test (SPT). Multivariate logistic regression analysis was used to obtain adjusted odds ratios (95% confidence interval) for each factor. For asthma, positive family history, male sex, low birth-weight, maternal smoking and season of birth were significant risk factors. For eczema, positive family history was the only significant risk factor. For rhinitis, lower socio-economic group and autumn birth were significant. Male sex and low birth-weight were significant for skin test positivity. Positive family history and low birth-weight were significant risk factors for any allergy. Low birth-weight was also a significant risk for skin test reactivity to house dust mite. Genetic and environmental factors have a profound effect on the development of allergic disorders in the first two years of life.