Autophagy and Caspases: A New Cell Death Program
Autophagy and Caspases: A New Cell Death Program
复制标题
DOI：
10.4161/cc.3.9.1097
复制
发表时间：
2004-07
期刊：
影响因子：
4.3
通讯作者：
Li Yu;M. Lenardo;E. Baehrecke
中科院分区：
文献类型：
--
作者：
Li Yu;M. Lenardo;E. Baehrecke
自噬用于降解细胞质的组分，并在营养剥夺期间作为细胞存活机制发挥作用。自噬结构也已在许多类型的垂死细胞中观察到，但自噬在程序性细胞死亡的调节中发挥作用的实验证据是有限的。我们最近发现，自噬基因Atg7和Beclin1是某些细胞死亡所必需的，从而证明这种蛋白水解机制与生存和死亡有关。使自噬能够调节不同的细胞存活和死亡反应的因素尚不清楚，未来的工作需要确定调节自噬细胞死亡的机制。
Autophagy is used to degrade components of the cytoplasm and functions as a cell survival mechanism during nutrient deprivation. Autophagic structures have also been observed in many types of dying cells, but experimental evidence for autophagy playing a role in the regulation of programmed cell death is limited. We have recently shown that the autophagy genes Atg7 and Beclin1 are required for the death of certain cells, thus demonstrating that this mechanism of proteolysis is involved in both survival and death. The factors that enable autophagy to regulate distinct cell survival and death responses are not clear, and future work is needed to determine the mechanism(s) that regulate autophagic cell death.