Effects of ethanol on nonspatial working memory and attention in rats.
Effects of ethanol on nonspatial working memory and attention in rats.
复制标题
乙醇对大鼠非空间工作记忆和注意力的影响。
DOI：
10.1037//0735-7044.111.2.275
复制
发表时间：
1997
影响因子：
1.9
通讯作者：
McMahon,K
中科院分区：
文献类型：
--
作者：
Givens,B;McMahon,K
研究乙醇诱导的认知功能障碍的神经基础需要使用有效的动物模型。一个操作性信号检测程序的开发，同时评估的过程中持续的注意和工作记忆的大鼠，并确定乙醇对这些认知功能的影响。乙醇，在0.75 g/kg腹腔注射/ly（ip），产生延迟和刺激长度依赖性减少选择的准确性，效果是一致的赤字在工作记忆和持续的注意。直接将乙醇局部注入内侧隔区域导致长时间延迟时选择准确性的选择性丧失。隔内乙醇的损害与刺激长度没有相互作用。因此，工作记忆障碍，而不是持续注意力的下降，是模仿隔内乙醇。目前的模型为研究乙醇认知效应的神经基础提供了基础。（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Investigation into the neural basis for ethanol-induced cognitive dysfunction requires the use of valid animal models. An operant signal detection procedure was developed to assess simultaneously the processes of sustained attention and working memory in rats, and to determine the effects of ethanol on these cognitive functions. Ethanol, at 0.75 g/kg intraperitoneal/ly (ip), produced delay-and stimulus length-dependent decreases in choice accuracy, effects that are consistent with deficits in both working memory and sustained attention. Local infusion of ethanol directly into the medial septal area resulted in a selective loss of choice accuracy at the long delay. The impairment by intraseptal ethanol did not interact with stimulus length. Thus, the working memory impairment, but not the decrement in sustained attention, was mimicked by intraseptal ethanol. The current model provides a foundation for studying the neural basis of ethanol's cognitive effects.(PsycINFO Database Record (c) 2016 APA, all rights reserved)