Current questions and possible controversies in autophagy.
Current questions and possible controversies in autophagy.
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当前的问题和自噬中可能的争议。
DOI：
10.1038/cddiscovery.2015.36
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发表时间：
2015
影响因子：
7
通讯作者：
Baehrecke EH
中科院分区：
文献类型：
--
作者：
Lindqvist LM;Simon AK;Baehrecke EH
在过去的十年中，对自噬的兴趣激增，出版物强调了与其他几个细胞过程的串扰，包括分泌，内吞作用和细胞自杀途径，包括凋亡。自噬蛋白也涉及其他独立于自噬作用的细胞过程，这使得自噬（Atg）突变基因数据的解释变得复杂。有趣的是，这种自噬过程是一种生存机制，也可以促进细胞死亡，但自噬何时以及如何“改变”其功能仍在争论中。事实上，目前有许多自噬如何影响细胞死亡的模型。在这篇综述中，我们强调了自噬领域的一些突出问题和可能存在的争议。
Interest in autophagy has exploded over the last decade, with publications highlighting crosstalk with several other cellular processes including secretion, endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins have also been implicated in other cellular processes independently of their roles in autophagy, creating complexities in the interpretation of autophagy (Atg) mutant gene data. Interestingly, this self-eating process is a survival mechanism that can also promote cell death, but when and how autophagy may ‘switch’ its function is still under debate. Indeed, there are currently many models of how autophagy actually influences cell death. In this review, we highlight some outstanding questions and possible controversies in the autophagy field.