Assessment of the interaction between aquatic colloids and pharmaceuticals facilitated by cross-flow ultrafiltration.
Assessment of the interaction between aquatic colloids and pharmaceuticals facilitated by cross-flow ultrafiltration.
复制标题
DOI：
10.1021/es071507d
复制
发表时间：
2007-10
影响因子：
11.4
通讯作者：
K. Maskaoui;A. Hibberd;John L. Zhou
中科院分区：
文献类型：
--
作者：
K. Maskaoui;A. Hibberd;John L. Zhou
药物和水生胶体之间的相互作用是调节其环境命运的关键过程，但人们对此知之甚少。使用经过验证的错流超滤 (CFUF) 系统来分离河流胶体，并通过液相色谱-串联质谱 (LC-MS-MS) 确定所选药物在胶体相（>1 kDa 但<0.7 微米）和溶解相（<1 kDa）之间的分配。药物与胶体结合的动力学很快，5 分钟内达到平衡。通过 CFUF 系统所选药物的质量平衡令人满意，包括普萘洛尔、磺胺甲恶唑、美贝维林、卡马西平、吲哚美辛、双氯芬酸和甲氯芬那酸。所选药物的归一化为胶体有机碳含量 (Kcoc) 的分配系数在 5.45 x 10(4) 至 7.54 x 10(5) mL/g 之间变化，大于内分泌干扰化学品 (EDC) 的分配系数，表明与药物的胶体相互作用强于与 EDC 的胶体相互作用。 log-Kcoc 与 log Kow（辛醇-水分配系数）等药物特性之间存在线性关系，凸显了化合物疏水性在控制其与胶体结合方面的重要性。这一发现与 Kcoc 值独立于 Kow 值的 EDC 的结果形成鲜明对比。 CFUF-LCMS 技术有潜力成为一种广泛适用的工具，用于量化纳米粒子和溶解相之间新兴有机污染物的分布。
Interactions between pharmaceuticals and aquatic colloids are a key process regulating their environmental fate, but poorly understood. A validated cross-flow ultrafiltration (CFUF) system was used to isolate river colloids and to determine the partition of selected pharmaceuticals between colloidal (>1 kDa but <0.7 microm) and dissolved phases (<1 kDa) by liquid chromatography-tandem mass spectrometry (LC-MS-MS). The kinetics of pharmaceutical binding to colloids was rapid, reaching equilibrium within 5 min. The mass balance of chosen pharmaceuticals through CFUF system was satisfactory for propranolol, sulfamethoxazole, meberverine, carbamazepine, indomethacine, diclofenac, and meclofenamic acid. The partition coefficient normalized to colloidal organic carbon content (Kcoc) varied from 5.45 x 10(4) to 7.54 x 10(5) mL/g for the chosen pharmaceuticals, which are greater than those for endocrine disrupting chemicals (EDCs), suggesting substantially stronger colloidal interactions with pharmaceuticals than with EDCs. Linear relationships were demonstrated between log-Kcoc, and pharmaceutical properties such as log Kow (octanol-water partition coefficient), highlighting the importance of compound hydrophobicity in controlling their binding with colloids. Such a finding is in contrast to that for EDCs whose Kcoc values were independent of their Kow values. The CFUF-LCMS technique has the potential to become a widely applicable tool for quantifying the distribution of emerging organic pollutants between nanoparticles and the dissolved phase.