Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles
Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles
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DOI：
10.1016/j.ejps.2006.06.003
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发表时间：
2006-10-01
影响因子：
4.6
通讯作者：
Hubbell, Jeffrey A.
中科院分区：
文献类型：
--
作者：
Missirlis, Dimitrios;Kawamura, Ryuzo;Hubbell, Jeffrey A.
我们最近描述了通过反相乳液光聚合制备的由聚（乙二醇）和泊洛沙姆407（Pluronic（R）F127）组成的稳定的聚合物纳米颗粒的制备。在本研究中，我们报告了这种新型胶体系统作为小型疏水性药物受控递送系统的性能。阿霉素的成功封装发生通过疏水相互作用，利用颗粒纳米结构。负载量高达8.7 wt.%用可重复的、快速的溶剂蒸发程序实现。通过荧光光谱法和HPLC监测的体外药物释放揭示了轻微的突释（在37 ° C下约10%）和持续的扩散释放超过1周;此外，药物包封显著延迟了阿霉素降解动力学。(c)2006年由Elsevier B. V.出版
We have recently described the preparation of stable, polymeric nanoparticles, composed of poly(ethylene glycol) and poloxamer 407 (Pluronic (R) F127), prepared via inverse emulsion photopolymerization. In the present study we report on the performance of this novel colloidal system as a controlled delivery system for small hydrophobic drugs. Successful encapsulation of doxorubicin occurred through hydrophobic interactions, taking advantage of particle nanoarchitecture. Loadings of up to 8.7 wt.% were achieved with a reproducible, fast, solvent evaporation procedure. In vitro drug release, monitored by fluorescence spectrometry and HPLC, revealed a minor burst (approximately 10% at 37 degrees C) and sustained, diffusional release for over 1 week; furthermore, drug encapsulation significantly delayed doxorubicin degradation kinetics. (c) 2006 Published by Elsevier B.V.