Whole-heart modelling with valves in a fluid-structure interaction framework
Whole-heart modelling with valves in a fluid-structure interaction framework
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DOI：
10.1016/j.cma.2023.116724
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发表时间：
2024-01-04
影响因子：
7.2
通讯作者：
Luo，Xiaoyu
中科院分区：
文献类型：
--
作者：
Feng，Liuyang;Gao，Hao;Luo，Xiaoyu
全心脏功能的计算模型是研究心脏力学和血液动力学的有用工具。现有的心脏模型大多集中在机电方面，没有考虑生理瓣膜，而是使用简化的流体模型。在这项研究中，我们开发了一个四腔心脏模型，具有逼真的腔室几何形状，详细的瓣膜建模，超弹性纤维结构和流体结构相互作用分析。我们的模型用于研究具有不同建模假设的心脏行为，包括受限/自由瓣膜环动力学，以及有/没有心脏-心包相互作用。我们的模拟结果捕捉瓣叶和周围的流动，典型的左心室流动涡流，典型的静脉和跨瓣流动波形，和生理心脏变形，如房室平面运动之间的相互作用。游离瓣环可明显改善早期心室充盈和心房排空。此外，我们发现，心脏上的附加心包力对心房壁变形有显著影响，特别是在心房收缩期间，并进一步帮助心房充盈过程。最重要的是，目前的研究提供了一个综合多物理全心脏建模的框架，考虑到所有心脏瓣膜和流体-结构相互作用。
Computational modelling of whole-heart function is a useful tool to study heart mechanics and haemodynamics. Many existing heart models focus on electromechanical aspect without considering physiological valves and use simplified fluid models instead. In this study we develop a four-chamber heart model featuring realistic chamber geometry, detailed valve modelling, hyperelasticity with fibre architecture and fluid–structure interaction analysis. Our model is used to investigate heart behaviours with different modelling assumptions including restricted/free valve annular dynamics, and with/without heart-pericardium interactions. Our simulation results capture the interactions between valve leaflet and surrounding flow, typical left ventricular flow vortices, typical venous and transvalvular flow waveform, and physiological heart deformations such as atrioventricular plane movement. The improvement of ventricular filling and atrial emptying at early diastole is evident with free annulus. In addition, we find that the added pericardial forces on the heart have a predominant effect on atrial wall deformation especially during atrial contraction, and further help with the atrial filling process. Most importantly, the current study provides a framework for comprehensive multi-physics whole-heart modelling considering all heart valves and fluid–structure interactions.