Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model
Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model
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三七皂苷治疗阿尔茨海默病小鼠模型中阿尔茨海默病相关环状 RNA 差异表达谱的鉴定
DOI：
10.1016/j.csbj.2018.10.010
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发表时间：
2018-01-01
影响因子：
6
通讯作者：
Wu, Deng-Pan
中科院分区：
文献类型：
--
作者：
Huang, Jin-Lan;Xu, Zhe-Hao;Wu, Deng-Pan
环状RNA（circRNA）在AD发病机制中起重要作用。因此，开发靶向circRNA的治疗候选物可以为AD治疗提供新的治疗策略。我们前期的研究表明三七总皂苷（PNS）对AD的病理进程有明显的抑制作用。然而，PNS减轻AD进展的机制仍不清楚。本研究表明，三七总皂苷可能具有调节AD相关circRNA表达的能力。具体而言，PNS治疗导致5种circRNA上调和2种circRNA下调，表明PNS对AD的治疗作用可能与其在circRNA表达调节中的作用有关。接下来，选择mmu_circRNA_013636和mmu_circRNA_012180，并进行GO和KEGG分析，以进一步研究这些circRNA的生物学功能和潜在机制。结果表明，筛选出的circRNA参与了AD相关的生物学过程和途径，提示这些circRNA可能参与了AD的发病机制。综上所述，我们的研究表明三七总皂苷对AD的治疗作用可能是通过调节AD相关circRNA的表达，提示三七总皂苷是一种潜在的circRNA靶向抗AD药物，这可能为开发针对circRNA的抗AD候选药物提供有用的资源。(C)2018作者由爱思唯尔公司出版
Circular RNAs (circRNAs) play vital roles in AD pathogenesis. Thus, developing therapeutic candidates targeting circRNA may provide a novel therapeutic strategy for AD treatment. Our previous studies showed that Panax notoginseng saponins (PNS) could significantly prohibit the pathological progress of AD. However, the mechanisms by which PNS attenuates AD progression is still unclear. The present study shows that PNS may exhibit an ability to modulate the expression of AD-associated circRNAs. Specifically, PNS treatment leads to five circRNAs upregulation and two circRNAs downregulation, indicating that the therapeutic effect of PNS against AD may be associated with its role in the regulation of circRNA expression. Next, mmu_circRNA_013636 and mmu_circRNA_012180 were selected and GO and KEGG analyses were performed to further investigate the biological functions and potential mechanisms of these circRNAs. The results showed that the selected circRNAs were involved in AD-associated biological process and pathways, suggesting that these circRNAs may participate in AD pathogenesis. Collectively, our study indicates that the therapeutic effects of PNS on AD may be through modulating the expression of AD associated circRNAs and suggests that PNS is a potential circRNA-targeted agent against AD, which may provide useful resources for developing potential candidates targeting circRNAs against AD. (C) 2018 The Authors. Published by Elsevier B.V.