ENLARGEMENT OF FOVEAL AVASCULAR ZONE IN DIABETIC EYES EVALUATED BY EN FACE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
ENLARGEMENT OF FOVEAL AVASCULAR ZONE IN DIABETIC EYES EVALUATED BY EN FACE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
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DOI：
10.1097/iae.0000000000000849
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发表时间：
2015-11-01
影响因子：
3.3
通讯作者：
Ogura, Yuichiro
中科院分区：
文献类型：
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作者：
Takase, Noriaki;Nozaki, Miho;Ogura, Yuichiro
目的：评价健康眼和糖尿病眼直视OCTA （AngioVue、Avanti OCT、Optovue）检测到的中央凹无血管区（FAZ）面积。方法：对接受眼底检查的患者进行回顾性图表分析，包括正面OCTA检查。排除有增殖性糖尿病视网膜病变和激光光凝史的眼睛。采用ImageJ软件测量和评价浅层和深层神经丛的FAZ面积。结果：正常眼（n = 19）浅层FAZ面积为0.25 0.06 mm(2)，无视网膜病变的糖尿病眼（n = 24）浅层FAZ面积为0.37 +/- 0.07 mm(2)，有糖尿病视网膜病变的眼（n = 20）浅层FAZ面积为0.38 +/- 0.11 mm(2)。与健康眼相比，糖尿病眼的FAZ增大具有统计学意义（P < 0.01），与是否存在视网膜病变无关。糖尿病眼深神经丛层FAZ面积明显大于正常眼（P < 0.01）。结论：我们的数据表明，糖尿病患者在视网膜病变发生之前就已经表现出黄斑视网膜微循环损伤。表面OCTA是一种有效的无创筛查工具，用于检测糖尿病患者早期微循环障碍。
Purpose: To evaluate the area of the foveal avascular zone (FAZ) detected by en face OCTA (AngioVue, Avanti OCT; Optovue) in healthy and diabetic eyes.Methods: Retrospective chart review of patients who underwent fundus examination including en face OCTA. Eyes with proliferative diabetic retinopathy and history of laser photocoagulation were excluded. The FAZ area in the superficial and deep plexus layers were measured and evaluated using ImageJ software.Results: The FAZ area in the superficial layer was 0.25 0.06 mm(2) in healthy eyes (n = 19), whereas it was 0.37 +/- 0.07 mm(2) in diabetic eyes without retinopathy (n = 24) and 0.38 +/- 0.11 mm(2) in eyes with diabetic retinopathy (n = 20). Diabetic eyes showed statistically significant FAZ enlargement compared with healthy eyes, regardless of the presence of retinopathy (P < 0.01). The FAZ area in the deep plexus layer was also significantly larger in diabetic eyes than in healthy eyes (P < 0.01).Conclusion: Our data suggest that diabetic eyes show retinal microcirculation impairment in the macula even before retinopathy develops. En face OCTA is a useful noninvasive screening tool for detecting early microcirculatory disturbance in patients with diabetes.