Androgens as adjuvant treatment in postmenopausal female patients with rheumatoid arthritis
Androgens as adjuvant treatment in postmenopausal female patients with rheumatoid arthritis
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DOI：
10.1136/ard.55.11.811
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发表时间：
1996-11-01
影响因子：
27.4
通讯作者：
Bijlsma, JWJ
中科院分区：
文献类型：
--
作者：
Booij, A;Biewengabooij, CM;Bijlsma, JWJ
107名妇女参加了一个双盲安慰剂对照试验，以评估50毫克丙酸睾酮肌肉注射每两周一year.Results-An改善ESR，荷兰健康评估问卷，和疼痛的影响。此外，21%的睾酮治疗患者在一年后达到ACR改善标准，而安慰剂组仅为4%。治疗耐受性良好。结论-替吉奥可以改善绝经后妇女活动性类风湿关节炎的总体健康。
Objective-To examine the possible beneficial effect of androgens in postmenopausal women with active rheumatoid arthritis.Methods-107 women participated in a double blind placebo controlled trial to evaluate the effect of 50 mg testosterone propionate intramuscularly every two weeks for one year.Results-An improvement in ESR, Dutch health assessment questionnaire, and pain was noted. In addition, 21% of patients treated with testosterone fulfilled the ACR improvement criteria after one year, versus only 4% of the placebo group. The treatment was well tolerated.Conclusions-Testosterone may improve the general wellbeing of postmenopausal women with active rheumatoid arthritis.