Childhood leukaemia and exposure to pesticides: Results of a case-control study in Northern Germany
Childhood leukaemia and exposure to pesticides: Results of a case-control study in Northern Germany
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DOI：
10.1016/0959-8049(96)00231-6
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发表时间：
1996-10-01
影响因子：
8.4
通讯作者：
Michaelis, J
中科院分区：
文献类型：
--
作者：
Meinert, R;Kaatsch, P;Michaelis, J
在德国北部下萨克森州进行的一项基于人群的病例对照研究中，研究了儿童白血病与农药接触之间的关系。在1988年7月至1992年6月期间，219例新诊断病例被确定，其中173人参加了研究。招募了两个性别和年龄匹配的对照组：来自与新诊断的白血病病例相同社区的当地对照组和来自下萨克森州其他随机选择的社区的国家对照组。另一个研究组包括175例实体肿瘤患者。当白血病病例与当地对照比较时，观察到与父母职业暴露，特别是与农业相关的暴露呈正相关，这在统计学上不显著。园林中农药的使用显著相关（优势比= 2.52,95%可信区间：1.0-6.1）。当将白血病病例与国家控制组进行比较时，没有发现正相关，但这一发现可以解释为生活在农村地区的国家控制组的比例更高。在过去十年（1984-1993年）儿童白血病标准化发病率显著升高的社区中，菜园农药使用率为21%，而其他社区为10%。所有被检查的危险因素在实体瘤病例中都不常见。我们的研究结果为农药是儿童白血病危险因素的假设增加了一些证据，并且有很好的理由认为农村地区大量使用农药可能是儿童白血病聚集的原因。版权所有爱思唯尔科学有限公司
The association between childhood leukaemia and exposure to pesticides was examined in a population-based case-control study conducted in Lower Saxony, Northern Germany. Between July 1988 and June 1992, 219 newly diagnosed cases were identified, of whom 173 participated in the study. Two sex- and age-matched control groups were recruited: local controls from the same communities as the newly diagnosed cases of leukaemia and state controls from other randomly selected communities in Lower Saxony. An additional study group consisted of 175 cases of solid tumours. When the leukaemia cases were compared with the local controls, positive associations with parental occupational exposure, particularly agriculture-related exposure, were observed, which were statistically non-significant. A significant association was found for pesticide use in gardens (odds ratio = 2.52, 95% confidence interval: 1.0-6.1). No positive associations were seen when the leukaemia cases were compared to the state controls, but this finding could be explained by a higher proportion of state controls living in rural areas. In communities with a significantly elevated standardised incidence ratio of childhood leukaemia over the last decade (1984-1993), the prevalence of pesticide use in the garden was 21%, compared with the 10% in other communities. None of the examined risk factors were more common among cases of solid tumours. Our findings add some evidence to the hypothesis that pesticides are a risk factor for childhood leukaemia, and there are good reasons to consider abundant pesticide use in rural areas as a possible cause for clustering of childhood leukaemia. Copyright (C) 1996 Elsevier Science Ltd