Neuropsychological characteristics of mild cognitive impairment subgroups
Neuropsychological characteristics of mild cognitive impairment subgroups
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DOI：
10.1136/jnnp.2004.045567
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发表时间：
2006-02-01
影响因子：
11
通讯作者：
Kuller, LH
中科院分区：
文献类型：
--
作者：
Lopez, OL;Becker, JT;Kuller, LH
目的：目的：描述心血管健康研究（CHS）认知功能研究中发现的轻度认知功能损害（MCI）亚组的神经心理学特征。方法：MCI分为MCI遗忘型（MCI AT）和MCI多重认知功能损害型（MCI AT），MCI AT为有记忆障碍但认知功能正常的患者（MCI-MCDT）：至少一个认知领域（不包括记忆）受损，或至少两个其他领域的一项异常测试，但未超过痴呆阈值。MCI受试者没有全身性，神经系统，或精神疾病可能会影响cognition.Results：MCI-AT（n = 10）的言语和非言语记忆性能比MCI-MCDT（n = 28）或正常对照组（n = 374）。相比之下，MCI-MCDT的语言，心理速度，精细运动控制和视觉结构功能比MCI-AT或正常对照组差。MCI-MCDT受试者有记忆缺陷，尽管它们不如MCI-AT明显。在MCI-MCDT组中，22例（78.5%）有记忆障碍，6例（21.5%）无记忆障碍。有记忆障碍的MCI-MCDT比无记忆障碍的MCI-MCDT有更多的语言障碍。相比之下，无记忆缺陷的MCI-MCDT比有记忆缺陷的MCI-MCDT有更多的精细运动控制缺陷。结论：MCI最常见的形式是记忆缺陷的MCI-MCDT。然而，记忆受损MCI组的识别并不能反映MCI在人群中的真实患病率，因为所有MCI病例中有16%和MCI-MCDT病例中有21.5%没有记忆受损。特发性遗忘和非遗忘型MCI的研究对于了解MCI的病因至关重要。
Objective: To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) cognition study.Methods: MCI was classified as MCI-amnestic type (MCI-AT): patients with documented memory deficits but otherwise normal cognitive function; and MCI-multiple cognitive deficits type (MCI-MCDT): impairment of at least one cognitive domain (not including memory), or one abnormal test in at least two other domains, but who had not crossed the dementia threshold. The MCI subjects did not have systemic, neurological, or psychiatric disorders likely to affect cognition.Results: MCI-AT (n = 10) had worse verbal and non-verbal memory performance than MCI-MCDT (n = 28) or normal controls (n = 374). By contrast, MCI-MCDT had worse language, psychomotor speed, fine motor control, and visuoconstructional function than MCI-AT or normal controls. MCI-MCDT subjects had memory deficits, though they were less pronounced than in MCI-AT. Of the MCI-MCDT cases, 22 (78.5%) had memory deficits, and 6 (21.5%) did not. MCI-MCDT with memory disorders had more language deficits than MCI-MCDT without memory disorders. By contrast, MCI-MCDT without memory deficits had more fine motor control deficits than MCI-MCDT with memory deficits.Conclusions: The most frequent form of MCI was the MCI-MCDT with memory deficits. However, the identification of memory impaired MCI groups did not reflect the true prevalence of MCI in a population, as 16% of all MCI cases and 21.5% of the MCI-MCDT cases did not have memory impairment. Study of idiopathic amnestic and non-amnestic forms of MCI is essential for an understanding of the aetiology of MCI.