Evaluating Changes in Tendon Crimp With Fatigue Loading as an Ex Vivo Structural Assessment of Tendon Damage
Evaluating Changes in Tendon Crimp With Fatigue Loading as an Ex Vivo Structural Assessment of Tendon Damage
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DOI：
10.1002/jor.22875
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发表时间：
2015-06-01
影响因子：
2.8
通讯作者：
Soslowsky, Louis J.
中科院分区：
文献类型：
--
作者：
Freedman, Benjamin R.;Zuskov, Andrey;Soslowsky, Louis J.
预应力筋的复杂结构与其力学性能密切相关。先前的研究已经将胶原纤维（卷曲）在准静态拉伸载荷期间的波纹度与拉伸机械性能相关联，但是关于疲劳载荷对卷曲性能的作用知之甚少。在这项研究（IACUC批准）中，小鼠髌腱疲劳加载，同时集成平面偏光镜同时评估压握性能。我们证明了一种新的结构机制，肌腱卷曲的幅度和频率与疲劳载荷的变化。特别是，疲劳载荷增加了跨肌腱宽度和长度的卷曲幅度，并且这些结构变化被证明是区域和载荷相关的。在评价的所有载荷和区域中，压握振幅的变化与机械组织松弛度（定义为位移和标距长度相对于整个试验期间在恒定载荷下评估的第一个疲劳载荷循环的比值）密切相关。总之，这项研究强调了疲劳载荷对肌腱压接性能的作用，作为施加载荷和评价区域的函数，并为可能导致最终肌腱失效的机械改变提供了额外的结构机制。(c)2015骨科研究学会。由威利期刊公司出版J Orthop Res 33：904-910，2015.
The complex structure of tendons relates to their mechanical properties. Previous research has associated the waviness of collagen fibers (crimp) during quasi-static tensile loading to tensile mechanical properties, but less is known about the role of fatigue loading on crimp properties. In this study (IACUC approved), mouse patellar tendons were fatigue loaded while an integrated plane polariscope simultaneously assessed crimp properties. We demonstrate a novel structural mechanism whereby tendon crimp amplitude and frequency are altered with fatigue loading. In particular, fatigue loading increased the crimp amplitude across the tendon width and length, and these structural alterations were shown to be both region and load dependent. The change in crimp amplitude was strongly correlated to mechanical tissue laxity (defined as the ratio of displacement and gauge length relative to the first cycle of fatigue loading assessed at constant load throughout testing), at all loads and regions evaluated. Together, this study highlights the role of fatigue loading on tendon crimp properties as a function of load applied and region evaluated, and offers an additional structural mechanism for mechanical alterations that may lead to ultimate tendon failure. (c) 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:904-910, 2015.