REJECTION OF THE INTESTINAL PARASITE NIPPOSTRONGYLUS-BRASILIENSIS BY MAST CELL-DEFICIENT W-W-UPSILON ANEMIC MICE
REJECTION OF THE INTESTINAL PARASITE NIPPOSTRONGYLUS-BRASILIENSIS BY MAST CELL-DEFICIENT W-W-UPSILON ANEMIC MICE
复制标题
DOI：
10.1128/iai.33.1.54-58.1981
复制
发表时间：
1981-01-01
影响因子：
3.1
通讯作者：
REED, ND
中科院分区：
文献类型：
--
作者：
CROWLE, PK;REED, ND
W/W.upsilon 的能力。研究人员检查了贫血小鼠积聚粘膜肥大细胞并排斥肠道寄生虫巴西奈瑟氏菌的能力。 W/W.upsilon。小鼠不会因巴西奈瑟氏球菌感染而积累粘膜肥大细胞。它们消除初次感染的速度比正常同窝对照的速度慢，但与对照组一样难以抵抗第二次和第三次感染。 W/W.upsilon。小鼠的蠕虫特异性 IgE 血清滴度高于对照组。粘膜肥大细胞并不是巴西奈瑟菌排斥反应的绝对必要条件。
The ability of W/W.upsilon. anemic mice to accumulate mucosal mast cells and to reject the intestinal parasite N. brasiliensis was examined. W/W.upsilon. mice did not accumulate mucosal mast cells in response to infections with N. brasiliensis. They eliminated a primary infection more slowly than did their normal littermate controls but were as refractory as controls to 2nd and 3rd infections. W/W.upsilon. mice had higher serum titers of worm-specific IgE than did controls. Mucosal mast cells are not an absolute requirement for N. brasiliensis rejection.