Quantitative multi-parameter mapping of R1, PD(*), MT, and R2(*) at 3T: a multi-center validation.
Quantitative multi-parameter mapping of R1, PD(*), MT, and R2(*) at 3T: a multi-center validation.
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DOI：
10.3389/fnins.2013.00095
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发表时间：
2013
影响因子：
4.3
通讯作者：
Lutti A
中科院分区：
文献类型：
--
作者：
Weiskopf N;Suckling J;Williams G;Correia MM;Inkster B;Tait R;Ooi C;Bullmore ET;Lutti A
使用磁共振成像的多中心研究有助于研究小效应量、全球人群方差和罕见疾病。这些多中心研究的可靠性和灵敏度主要取决于不同研究中心和时间点生成的数据的可比性。对于常规解剖T1加权MRI数据，临床试验机构间的可比性水平仍存在争议。定量多参数标测（MPM）旨在提供不同研究中心和时间点之间具有可比性的MR参数测量，即，纵向弛豫速率（R1 = 1/T1）、有效质子密度（PD*）、磁化转移饱和度（MT）和有效横向弛豫速率（R2* = 1/T2*）的1 mm高分辨率图。通过在三个不同的研究中心扫描五名志愿者，在3 T下验证了MPM用于多中心研究。我们确定了典型形态测量的位点间偏倚、位点间和位点内变异系数（CoV）[即，在基于体素的形态测量中使用的灰质（GM）概率图]和四个定量参数。除R2* 的中心间CoV（<20%）外，中心间偏倚和CoV分别小于3.1%和8%。基于MT参数图的GM概率图比基于传统T1加权图像的图具有高14%的站点间再现性。参数和衍生GM概率图的低中心间偏倚和方差证实了各中心和时间点间定量图的高度可比性。MPM的可靠性、短采集时间、高分辨率和对大脑微观结构的详细了解使其成为多中心成像研究的有效工具。
Multi-center studies using magnetic resonance imaging facilitate studying small effect sizes, global population variance and rare diseases. The reliability and sensitivity of these multi-center studies crucially depend on the comparability of the data generated at different sites and time points. The level of inter-site comparability is still controversial for conventional anatomical T1-weighted MRI data. Quantitative multi-parameter mapping (MPM) was designed to provide MR parameter measures that are comparable across sites and time points, i.e., 1 mm high-resolution maps of the longitudinal relaxation rate (R1 = 1/T1), effective proton density (PD*), magnetization transfer saturation (MT) and effective transverse relaxation rate (R2* = 1/T2*). MPM was validated at 3T for use in multi-center studies by scanning five volunteers at three different sites. We determined the inter-site bias, inter-site and intra-site coefficient of variation (CoV) for typical morphometric measures [i.e., gray matter (GM) probability maps used in voxel-based morphometry] and the four quantitative parameters. The inter-site bias and CoV were smaller than 3.1 and 8%, respectively, except for the inter-site CoV of R2* (<20%). The GM probability maps based on the MT parameter maps had a 14% higher inter-site reproducibility than maps based on conventional T1-weighted images. The low inter-site bias and variance in the parameters and derived GM probability maps confirm the high comparability of the quantitative maps across sites and time points. The reliability, short acquisition time, high resolution and the detailed insights into the brain microstructure provided by MPM makes it an efficient tool for multi-center imaging studies.
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影响因子：
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