Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid.
Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid.
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使用 13-顺式-视黄酸可延长囊性和球状痤疮的缓解。
DOI：
10.1056/nejm197902153000701
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
J. Arnaud
中科院分区：
文献类型：
--
作者：
G. Peck;T. Olsen;F. Yoder;J. Strauss;D. Downing;M. Pandya;D. Butkus;J. Arnaud
14名患有难治性囊性痤疮和小叶痤疮的患者接受了4个月的口服13-顺式维甲酸治疗，13-顺式维甲酸是天然存在的全反式维甲酸的合成异构体。平均剂量为2.0 mg/kg/天。13名患者经历了完全清除他们的疾病;另一个有75%的改善，这是由治疗前后存在的痤疮结节和囊肿的数量决定的。在所有14例患者中均观察到缓解期延长，目前在停止治疗后持续长达20个月。在大多数患者中，临床毒性仅限于皮肤和粘膜，并且具有剂量依赖性，并且在停止治疗后迅速可逆。13-顺式维甲酸治疗痤疮的作用机制可能涉及药物对皮脂腺的直接抑制作用。
Fourteen patients with treatment-resistant cystic and conglobate acne were treated for four months with oral 13-cis-retinoic acid, a synthetic isomer of naturally occurring all-trans-retinoic acid. The average dose was 2.0 mg per kilogram per day. Thirteen patients experienced complete clearing of their disease; the other had 75 per cent improvement, as determined by the number of acne nodules and cysts present before and after therapy. Prolonged remissions, currently lasting as long as 20 months after discontinuation of therapy, have been observed in all 14 patients. Clinical toxicity was limited to the skin and mucous membranes in most patients and was dose dependent and rapidly reversible upon discontinuation of therapy. The mechanism of action of 13-cis-retinoic acid in the therapy of acne probably involves a direct inhibitory effect of the drug on the sebaceous gland.