Low expression of DCXR protein indicates a poor prognosis for hepatocellular carcinoma patients.
Low expression of DCXR protein indicates a poor prognosis for hepatocellular carcinoma patients.
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DCXR蛋白的低表达表明肝细胞癌患者预后不良。
DOI：
10.1007/s13277-016-5302-9
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Xu Wensheng
中科院分区：
文献类型：
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作者：
Hang Xiaofeng;Wu Zhiqin;Chu Kaijian;Yu Guanzhen;Peng Haoran;Xin Haiguang;Miao Xiaohui;Wang Junxue;Xu Wensheng
本研究的目的是探讨二羰基/ l -木糖还原酶（DCXR）在人肝细胞癌（HCC）中的预后价值。免疫组织化学和组织微阵列检测DCXR蛋白表达水平。使用Image-Pro Plus计算每个组织样本的积分光密度（IOD）， IOD代表DCXR的表达水平。免疫组化分析74例配对肝癌组织及瘤周非癌组织DCXR蛋白水平，发现DCXR蛋白在HCC肿瘤组织中显著降低（P< 0.0001）。在290例训练组和74例验证组中评估了DCXR在HCC中的预后价值。在训练组和验证组中，较短的总生存期（OS）和较短的复发时间（TTR）被发现与较低的DCXR表达水平相关。在训练集中，根据单因素和多因素分析，DCXR在HCC中的表达水平是OS的独立预后因素。综上所述，DCXR表达是肝癌患者术后OS和TTR的独立预后因素，HCC中DCXR表达水平低可能提示肝癌患者手术切除后预后较差。
The aim of this study was to investigate the prognostic value of dicarbonyl/L-xylulose reductase (DCXR) in human hepatocellular carcinoma (HCC). Immunohistochemistry and tissue microarrays were used to evaluate DCXR protein expression levels. Image-Pro Plus was used to calculate the integral optic density (IOD) in each tissue sample, which represented the expression level of DCXR. DCXR proteins were found to be significantly lower in HCC tumor tissues (P< 0.0001) according to immunohistochemical analysis of DCXR protein levels in 74 paired HCC tissue and peritumoral non-cancer tissues. The prognostic value of DCXR in HCC was assessed in 290 cases of the training cohort and 74 cases of the validation cohort. Shorter overall survival (OS) time and shorter time to recurrence (TTR) in both the training and validation set were found to be associated with lower expression levels of DCXR. In the training set, the expression level of DCXR in HCC was an independent prognostic factor for OS according to univariate and multivariate analyses. In conclusion, DCXR expression is an independent prognostic factor for OS and TTR of post-operative HCC patients, and low expression levels of DCXR in HCC may indicate poor outcome of HCC patients after surgical resection.