Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis
Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis
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抗膜联蛋白 II 抗体与抗磷脂综合征和伴有血栓的系统性红斑狼疮中的血栓形成和/或妊娠发病率相关
DOI：
10.1007/s00296-010-1379-4
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发表时间：
2011-07-01
影响因子：
4
通讯作者：
Yang, Cheng-De
中科院分区：
文献类型：
--
作者：
Ao, Wen;Zheng, Hui;Yang, Cheng-De
本研究调查了抗磷脂综合征（APS）和系统性红斑狼疮（SLE）患者抗膜联蛋白II （A2）抗体的流行情况。并探讨了该抗体在血栓形成中的作用。采用ELISA法检测101例APS患者、41例合并血栓形成的SLE患者、124例未合并血栓形成的SLE患者和120例健康对照的IgG抗A2抗体水平。APS患者和合并血栓的SLE患者IgG抗a2抗体阳性率分别为21.8%和26.8%。这两个值均显著高于无血栓形成的SLE患者（6.5%）。IgG抗a2抗体与血栓形成和/或妊娠发病率相关（P < 0.001）。数据显示，APS患者和合并血栓的SLE患者抗a2抗体水平较高。此外，该抗体的存在与血栓形成和/或妊娠发病率相关，表明抗a2抗体可能有助于识别潜在的APS病例。
This study investigated the prevalence of antibody against annexin II (A2) in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). It also explored the role of this antibody in thrombosis. Purified recombinant A2 was used in ELISA to measure the levels of IgG anti-A2 antibody in 101 APS patients, 41 SLE patients with thrombosis, 124 SLE patients without thrombosis, and 120 healthy controls. The positive rates of IgG anti-A2 antibody in APS patients and SLE patients with thrombosis were 21.8 and 26.8%, respectively. Both values are significantly higher than that in SLE patients without thrombosis (6.5%). IgG anti-A2 antibody is associated with thrombosis and/or pregnancy morbidity (P < 0.001). The data show that the levels of anti-A2 antibody are higher in APS patients and SLE patients with thrombosis. Further, the presence of this antibody is associated with thrombosis and/or pregnancy morbidity, suggesting that anti-A2 antibody may be helpful in identifying potential APS cases.