The role of nuclear bodies in gene expression and disease.
The role of nuclear bodies in gene expression and disease.
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DOI：
10.3390/biology2030976
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发表时间：
2013-07-09
期刊：
影响因子：
4.2
通讯作者：
Boerkoel CF
中科院分区：
文献类型：
--
作者：
Morimoto M;Boerkoel CF
这篇综述总结了目前对核体在调节基因表达中的作用的理解。细胞过程的划分，例如核糖体生物合成、RNA 加工、细胞对应激的反应、转录、剪接体 snRNP 的修饰和组装、组蛋白基因合成和核 RNA 保留，对基因调控具有重要意义。这些功能性核结构域包括核仁、核斑点、核应激体、转录工厂、卡哈尔体、卡哈尔体双子座、组蛋白基因座体和副斑点。我们在此回顾核体在调节基因表达中的作用及其与人类健康和疾病的关系。
This review summarizes the current understanding of the role of nuclear bodies in regulating gene expression. The compartmentalization of cellular processes, such as ribosome biogenesis, RNA processing, cellular response to stress, transcription, modification and assembly of spliceosomal snRNPs, histone gene synthesis and nuclear RNA retention, has significant implications for gene regulation. These functional nuclear domains include the nucleolus, nuclear speckle, nuclear stress body, transcription factory, Cajal body, Gemini of Cajal body, histone locus body and paraspeckle. We herein review the roles of nuclear bodies in regulating gene expression and their relation to human health and disease.