Origins of Age-Related DNA Damage and Dietary Strategies for Its Reduction
Origins of Age-Related DNA Damage and Dietary Strategies for Its Reduction
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DOI：
10.1089/rej.2009.0945
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发表时间：
2010-04-01
影响因子：
2.6
通讯作者：
Shimizu, Masatomi
中科院分区：
文献类型：
--
作者：
Gruz, Petr;Shimizu, Masatomi
生物膜中的多不饱和脂肪酸既是氧化损伤的目标又是氧化损伤的来源，可以被视为体内最不稳定的一类生物分子。多不饱和脂肪酸的自发氧化和酶促氧化产生的脂质过氧化物是内源性 DNA 损伤的主要来源，该损伤与各种与年龄相关的病理学和引发癌变有关。在这里，我们描述了脂质过氧化物衍生的 DNA 加合物的主要类型，并提出了一种简单的饮食策略来减少其形成。这可能对衰老的有机体特别有益，因为它的自然保护系统逐渐受损。
The polyunsaturated fatty acids in biological membranes serve as both the target and source of oxidative damage and can be regarded as the most unstable class of biomolecules in the body. Lipid peroxides arising from both spontaneous and enzymatic oxidation of polyunsaturated fatty acids are the major source of endogenous DNA damage linked to various age-related pathologies and initiating carcinogenesis. Here we describe the major types of lipid peroxide-derived DNA adducts and propose a simple dietary strategy to reduce their formation. This may be particularly beneficial to the aging organism, which has progressively impaired natural protective systems.