Serotonin-induced spike narrowing in a locomotor pattern generator permits increases in cycle frequency during accelerations.
Serotonin-induced spike narrowing in a locomotor pattern generator permits increases in cycle frequency during accelerations.
复制标题
运动模式发生器中血清素引起的尖峰变窄允许加速期间循环频率的增加。
DOI：
10.1152/jn.2000.83.4.2163
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Pirtle,TJ
中科院分区：
文献类型：
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作者：
Satterlie,RA;Norekian,TP;Pirtle,TJ
在翼足类软体动物Clionelimacina中，在马槟榔宁诱导的游泳加速过程中，中央模式发生器（CPG）的中间神经元表现出显着的动作电位变窄。尖峰窄化显然是必要的周期频率增加游泳加速，因为，在没有窄化，合并的时间尖峰和抑制性突触后电位（IPSP）的一个单一的周期是大于可用的周期持续时间。尖峰窄化可负面影响所有中间神经元连接的突触效能，包括两组拮抗性CPG中间神经元之间的相互抑制连接以及中间神经元到运动神经元的连接。因此，必须存在补偿机制，以产生游泳加速的整体兴奋性行为变化。这些机制包括1）中间神经元的基线去极化，使它们更接近尖峰阈值，2）它们的抑制后反弹的增强，和3）游泳运动神经元和肌肉的直接调制，所有这些都是通过多巴胺能调节神经元的输入。
During serotonin-induced swim acceleration in the pteropod molluskClione limacina, interneurons of the central pattern generator (CPG) exhibit significant action potential narrowing. Spike narrowing is apparently necessary for increases in cycle frequency during swim acceleration because, in the absence of narrowing, the combined duration of the spike and the inhibitory postsynaptic potential (IPSP) of a single cycle is greater than the available cycle duration. Spike narrowing could negatively influence synaptic efficacy in all interneuron connections, including reciprocal inhibitory connections between the two groups of antagonistic CPG interneurons as well as the interneuron-to-motoneuron connections. Thus compensatory mechanisms must exist to produce the overall excitatory behavioral change of swim acceleration. Such mechanisms include1) a baseline depolarization of interneurons, which brings them closer to spike threshold,2) enhancement of their postinhibitory rebound, and3) direct modulation of swim motoneurons and muscles, all through inputs from serotonergic modulatory neurons.