Towards global consensus in the treatment of gastrointestinal stromal tumor.
Towards global consensus in the treatment of gastrointestinal stromal tumor.
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DOI：
10.1586/era.09.171
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发表时间：
2010-02
影响因子：
3.3
通讯作者：
Mehren Mv
中科院分区：
文献类型：
--
作者：
Reichardt P;Blay JY;Mehren Mv
胃肠道间质瘤(GIST)的当代临床图景在过去几年中迅速演变。来自欧洲医学肿瘤学会(ESMO)和国家综合癌症网络的广泛使用的治疗指南最近进行了更新，代表了指导GIST优化管理的最新、全面的工具。在这些以及其他已发表的指南中，现在与GIST管理相关的许多临床问题的建议密切一致-手术、酪氨酸激酶抑制剂伊马替尼和孙尼替尼的使用以及手术前和手术后伊马替尼的作用等。这种在治疗GIST方面达成全球共识的趋势是在其管理范围内获得相对大量的新数据的结果。然而，出于一些临床考虑，建议仍然部分偏离。本综述结合该领域的最新数据，着眼于包括外科肿瘤学、内科肿瘤学、病理学和诊断放射学在内的多学科方法，对胃肠道间质瘤的临床治疗建议和意见进行了审查。突出了共识的要点。就目前没有科学证据或明确建议的管理领域提出专家意见；包括挥之不去和悬而未决的问题或问题。在这个框架内，我们对GIST治疗中的以下领域的当前全球指南进行了评估：转移环境中的手术；新辅助治疗；辅助治疗；突变分析；维持酪氨酸激酶抑制剂治疗；以及GIST的放射成像。基于临床试验数据的这些指南的共识总结与专家意见并列，其中数据仍有差距。
The contemporary clinical landscape of gastrointestinal stromal tumor (GIST) has evolved rapidly over the past several years. Widely used treatment guidelines – from the European Society of Medical Oncology (ESMO) and the National Comprehensive Cancer Network – have recently been updated and represent the most up-to-date, comprehensive tools guiding the optimal management of GIST. In these, and in other published guidelines, close alignment among recommendations now exists for many of the clinical issues relevant to GIST management – surgery, use of the tyrosine kinase inhibitors imatinib and sunitinib and the role of pre- and post-operative imatinib, among others. This trend towards a global consensus in the treatment of GIST is the result of a relatively large amount of new data across the spectrum of its management. However, for some clinical considerations, recommendations still partially deviate. This review examines clinical recommendations and opinions on the management of GIST in the context of the latest data in the field and with an eye towards a multidisciplinary approach including surgical oncology, medical oncology, pathology and diagnostic radiology. Points of consensus are highlighted. Expert opinion is presented on management areas where no scientific evidence or firm recommendations currently exist; lingering and unresolved questions or issues are included. Within this framework, we present an evaluation of current global guidelines on the following areas in GIST management: surgery in the metastatic setting; neoadjuvant therapy; adjuvant therapy; mutational analysis; maintenance tyrosine kinase inhibitor therapy; and radiological imaging in GIST. A summary of consensus across these guidelines based on clinical trial data is juxtaposed with expert opinion where gaps in data still remain.
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影响因子：
2.5
作者：
Eisenberg, Burton L.;Harris, Jonathan;Blanke, Charles D.;Demetri, George D.;Heinrich, Michael C.;Watson, James C.;Hoffman, John P.;Okuno, Scott;Kane, John M.;von Mehren, Margaret
通讯作者：
von Mehren, Margaret
DOI：
10.1016/s1091-255x(98)80006-1
发表时间：
1998-03-01
期刊：
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
影响因子：
--
作者：
Chen, H;Pruitt, A;Choti, M A
通讯作者：
Choti, M A
影响因子：
45.3
作者：
Choi, Haesun;Charnsangavej, Chuslip;Benjamin, Robert S.
通讯作者：
Benjamin, Robert S.
影响因子：
45.3
作者：
Blay, Jean-Yves;Le Cesne, Axel;Perol, David
通讯作者：
Perol, David
影响因子：
6.4
作者：
Bauer, S;Hartmann, JT;Schütte, J
通讯作者：
Schütte, J