Risk factors for the development of lithium-induced polyuria
Risk factors for the development of lithium-induced polyuria
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锂诱发多尿症发生的危险因素
DOI：
10.1192/bjp.182.4.319
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发表时间：
2003
影响因子：
10.5
通讯作者：
A. Egberts
中科院分区：
文献类型：
--
作者：
K. Movig;R. Baumgarten;H. Leufkens;J. V. Van Laarhoven;A. Egberts
多尿症在锂治疗的双相情感障碍患者中很常见。然而，这些患者多尿的危险因素尚未确定。目的评估与使用锂相关的多尿患病率，并确定其他危险因素。方法对一家锂离子门诊进行为期4个月的前瞻性随访研究。75名参与者被要求提供24小时的尿液样本；多尿症被定义为每24小时尿量大于3升。检查的危险因素包括人口统计学变量、药物和医疗合并症。结果锂盐使用者多尿率为37%。与不使用这些药物的患者相比，同时使用5 -羟色胺类抗抑郁药与多尿症密切相关（优势比4.25,95% CI 1.15-15.68）。结论：我们的数据证实了锂诱发多尿的高患病率。医生应该意识到同时使用5 -羟色胺类抗抑郁药和锂会显著增加其发生的风险。虽然有限多尿是无害的，但它可能会给病人带来麻烦。在许多情况下，由于难以控制躁狂或抑郁症状，停止锂治疗不是一种选择。
Background Polyuria is common in patients with bipolar disorder treated with lithium. However, the risk factors for polyuria in these patients have not been established. Aims To estimate the prevalence of polyuria associated with the use of lithium and to identify additional risk factors. Method A 4-month prospective follow-up study in an out-patient lithium clinic. The 75 participants were asked to provide 24-h urine samples; polyuria was defined as a urine volume greater than 3 litres per 24 h. Risk factors examined included demographic variables, medications and medical comorbidities. Results The prevalence of polyuria among lithium users was 37%. Concomitant use of serotonergic antidepressants was strongly associated with polyuria (odds ratio 4.25, 95% CI 1.15–15.68) compared with patients not using these agents. Conclusions Our data confirm the high prevalence of lithium-induced polyuria. Physicians should be aware that concurrent use of serotonergic antidepressants and lithium significantly enhances the risk of its occurrence. Although limited polyuria is not harmful, it may be troublesome for the patient. In many cases cessation of lithium therapy is not an option because of difficulty in controlling the manic or depressive symptoms.
影响因子：
5
作者：
Tatsumi, M;Groshan, K;Richelson, E
通讯作者：
Richelson, E