Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease.
Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease.
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Myricetin可保护海马CA3锥体神经元，并改善患有阿尔茨海默氏病大鼠的学习和记忆障碍。
DOI：
10.4103/1673-5374.197141
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发表时间：
2016-12
影响因子：
6.1
通讯作者：
Hashemi A
中科院分区：
文献类型：
--
作者：
Ramezani M;Darbandi N;Khodagholi F;Hashemi A
目前尚无有效减缓阿尔茨海默病进展的治疗方法，因此早期预防非常重要。大量研究表明黄酮类化合物可以改善记忆障碍。本研究调查了杨梅素（黄酮类化合物的一种）对脑室内链脲佐菌素引起的阿尔茨海默病大鼠模型神经元损失和记忆障碍的影响。将 5 或 10 mg/kg 的杨梅素连续 21 天腹腔注射给大鼠。对照大鼠用10mL/kg盐水处理。第22天进行行为测试（穿梭箱测试）以检查大鼠的学习和记忆能力。随后立即进行苏木精-伊红染色，观察海马CA3锥体神经元的形态变化。杨梅素大大增加了海马 CA3 锥体神经元的数量，并改善了阿尔茨海默病大鼠的学习和记忆障碍。这些发现表明杨梅素有益于治疗阿尔茨海默病。
There is currently no treatment for effectively slowing the progression of Alzheimer's disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer's disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 mL/kg saline. Behavioral test (the shuttle box test) was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer's disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer's disease.