Neutrophil infiltration into human gliomas
Neutrophil infiltration into human gliomas
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DOI：
10.1007/s004010051093
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发表时间：
1999-10-01
影响因子：
12.7
通讯作者：
Rossi, ML
中科院分区：
文献类型：
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作者：
Fossati, G;Ricevuti, G;Rossi, ML
通过对 CD15 阳性和髓过氧化物酶阳性细胞的切片进行染色，使用免疫组织化学分析人神经胶质瘤的中性粒细胞浸润。超过 70% 的所有分析的神经胶质瘤样本 (n = 105) 具有显着的中性粒细胞浸润，但肿瘤分级和中性粒细胞浸润程度之间存在显着且显着的相关性。在低级别肿瘤中，只有 40-50% 具有显着浸润，而在多形性胶质母细胞瘤中，超过 85% 的分析样本具有显着浸润。浸润多形性胶质母细胞瘤肿瘤的中性粒细胞数量也多于其他肿瘤组。所有神经胶质瘤患者的循环白细胞计数均高于正常范围，但这种升高完全是由于循环中性粒细胞数量增加所致。同样，在多形性胶质母细胞瘤患者中观察到循环中性粒细胞数量最高。这些实验表明，神经胶质瘤衍生的因子可能直接或间接影响循环中性粒细胞的数量并影响它们对肿瘤的浸润。
Human gliomas were analysed for the infiltration of neutrophils using immunohistochemistry by staining sections for CD15-positive and myeloperoxidase-positive cells. Over 70% of all glioma samples analysed (n = 105) had significant neutrophil infiltration, but there was a marked and significant correlation between tumour grade and the extent of the neutrophil infiltration. In the low grade tumours only 40-50% had significant infiltration while in glioblastoma multiforme over 85% of the samples analysed had significant infiltration. Numbers of neutrophils infiltrating glioblastoma multiforme tumours were also greater than in the other tumour groups. Circulating white blood cell counts were elevated above the normal range in all glioma patients, but this elevation was entirely due to increased numbers of circulating neutrophils. Again, the highest numbers of circulating neutrophils were seen in the glioblastoma multiforme patients. These experiments indicate that glioma-derived factors may directly or indirectly affect the number of circulating neutrophils and influence their infiltration into the tumours.