A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters.
A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters.
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II 型脱碘酶基因的新多态性与循环甲状腺激素参数相关。
DOI：
10.1152/ajpendo.00571.2004
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
T. Visser
中科院分区：
文献类型：
--
作者：
R. Peeters;A. W. van den Beld;Hayat Attalki;H. Toor;Y. D. de Rijke;G. Kuiper;S. Lamberts;J. Janssen;A. Uitterlinden;T. Visser
II型脱碘酶（D2）在某些组织局部甲状腺激素生物活性的调节中起重要作用。骨骼肌中的D2也可能在血清三碘甲状腺原氨酸（T(3)）的产生中起作用。在这项研究中，我们发现了D2基因5'-UTR的多态性（D2- orfa - gly3asp）。我们研究了D2-ORFa-Gly3Asp和先前鉴定的D2-Thr92Ala多态性与血清碘甲状腺原氨酸水平的关系。D2-ORFa-Gly3Asp通过随机选择15个个体的5'-UTR测序鉴定。在156名健康献血者（年龄46.3 +/- 12.2岁）和349名流动老年男性（年龄77.7 +/- 3.5岁）中测定D2-ORFa-Gly3Asp基因型，并与血清碘甲状腺原氨酸和TSH水平相关。D2-ORFa-Asp(3)在血库献血者中等位基因频率为33.9%，与血清甲状腺素相关(T(4)；Gly/Gly vs. Gly/Asp vs. Asp/Asp = 7.06 +/- 0.14 vs. 6.74 +/- 0.15 vs. 6.29 +/- 0.27 μ g/dl, P = 0.01)，游离T(4) (1.22 +/- 0.02 vs. 1.16 +/- 0.02 vs. 1.06 +/- 0.04 ng/dl, P = 0.001)，逆T(3) (P = 0.01)， T(3)/T(4)比值（P = 0.002）呈剂量依赖性，但与血清T(3)无关（P = 0.59）。在老年男性中，D2-ORFa-Asp(3)有相似的频率，但与血清碘甲状腺原氨酸水平无关。这种D2 5'-UTR的新多态性与献血者的碘甲状腺原氨酸水平有关，但与老年男性无关。我们假设这可能是由于衰老过程中骨骼肌大小的下降，导致D2对血清T(3)生成的贡献相对减少。
Type II deiodinase (D2) is important in the regulation of local thyroid hormone bioactivity in certain tissues. D2 in skeletal muscle may also play a role in serum triiodothyronine (T(3)) production. In this study, we identified a polymorphism in the 5'-UTR of the D2 gene (D2-ORFa-Gly3Asp). We investigated the association of D2-ORFa-Gly3Asp, and of the previously identified D2-Thr92Ala polymorphism, with serum iodothyronine levels. D2-ORFa-Gly3Asp was identified by sequencing the 5'-UTR of 15 randomly selected individuals. Genotypes for D2-ORFa-Gly3Asp were determined in 156 healthy blood donors (age 46.3 +/- 12.2 yr) and 349 ambulant elderly men (age 77.7 +/- 3.5 yr) and related to serum iodothyronine and TSH levels. D2-ORFa-Asp(3) had an allele frequency of 33.9% in blood bank donors and was associated with serum thyroxine (T(4); Gly/Gly vs. Gly/Asp vs. Asp/Asp = 7.06 +/- 0.14 vs. 6.74 +/- 0.15 vs. 6.29 +/- 0.27 microg/dl, P = 0.01), free T(4) (1.22 +/- 0.02 vs. 1.16 +/- 0.02 vs. 1.06 +/- 0.04 ng/dl, P = 0.001), reverse T(3) (P = 0.01), and T(3)/T(4) ratio (P = 0.002) in a dose-dependent manner, but not with serum T(3) (P = 0.59). In elderly men, D2-ORFa-Asp(3) had a similar frequency but was not associated with serum iodothyronine levels. This new polymorphism in the 5'-UTR of D2 is associated with iodothyronine levels in blood donors but not in elderly men. We hypothesize that this might be explained by the decline in skeletal muscle size during aging, resulting in a relative decrease in the contribution of D2 to serum T(3) production.
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影响因子：
15.9
作者：
Croteau, W;Davey, JC;StGermain, DL
通讯作者：
StGermain, DL
mRNA 结构对 2 型碘甲状腺原氨酸脱碘酶表达具有有效的调节作用。
DOI：
10.1210/mend.16.7.0879
发表时间：
2002
期刊：
Molecular endocrinology (Baltimore, Md.)
影响因子：
--
作者：
Gereben,Balazs;Kollar,Anna;Harney,JohnW;Larsen,PReed
通讯作者：
Larsen,PReed
影响因子：
4.8
作者：
D. Salvatore;T. Bartha;J. Harney;P. Larsen
通讯作者：
D. Salvatore;T. Bartha;J. Harney;P. Larsen
影响因子：
20.3
作者：
A. Bianco;D. Salvatore;B. Gereben;Marla J. Berry;P. Larsen
通讯作者：
A. Bianco;D. Salvatore;B. Gereben;Marla J. Berry;P. Larsen
DOI：
10.1073/pnas.83.9.2850
发表时间：
1986-05-01
影响因子：
11.1
作者：
KOZAK, M
通讯作者：
KOZAK, M