Breast asymmetry and predisposition to breast cancer.
Breast asymmetry and predisposition to breast cancer.
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DOI：
10.1186/bcr1388
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Manning JT
中科院分区：
文献类型：
--
作者：
Scutt D;Lancaster GA;Manning JT
我们之前的研究表明，乳房不对称与乳腺癌的几个已知风险因素有关，并且通过乳房x光检查，诊断为乳腺癌的患者比同龄的健康女性乳房体积更不对称。在本研究中，我们比较了在乳房x光检查时没有乳房疾病但随后发展为乳腺癌的女性与年龄匹配的健康对照者的乳房不对称，这些对照者在本研究期间没有疾病。研究小组由252名无症状的妇女组成，她们进行了正常的乳房x光检查，但后来患上了乳腺癌。对照组是252名年龄匹配的健康对照者，他们的乳房x光检查也正常，在研究期间没有患癌症。通过每组的颅尾乳房x光片计算乳房体积，并探讨不对称、已确定的危险因素与是否存在乳腺癌之间的关系。继续发展为乳腺癌的组比对照组有更高的乳房不对称(绝对不对称优势比为1.50 / 100 ml，置信区间（CI） 1.10, 2.04；相对不对称1.09,CI 1.01, 1.18)，乳腺癌家族史发生率增高，初潮年龄较低，绝经期较晚，首次妊娠较晚，高危乳腺实质类型发生率较高。条件logistic回归分析显示，乳房不对称、身高、乳腺癌家族史、初潮年龄、实质类型和绝经状态是乳腺癌的显著独立预测因素。当绝经年龄被纳入绝经后妇女亚组的模型时，绝对乳房波动不对称（FA）和相对乳房FA仍然有显著影响。后来患乳腺癌的健康女性的乳房不对称比没有患乳腺癌的女性更严重。
It has been shown in our previous work that breast asymmetry is related to several of the known risk factors for breast cancer, and that patients with diagnosed breast cancer have more breast volume asymmetry, as measured from mammograms, than age-matched healthy women. In the present study, we compared the breast asymmetry of women who were free of breast disease at time of mammography, but who had subsequently developed breast cancer, with that of age-matched healthy controls who had remained disease-free to time of the present study. The study group consisted of 252 asymptomatic women who had normal mammography, but went on to develop breast cancer. The control group were 252 age-matched healthy controls whose mammograms were also normal and who remained free of cancer during the study period. Breast volume was calculated from the cranio-caudal mammograms for each group, and the relationships between asymmetry, established risk factors and the presence or absence of breast cancer were explored. The group who went on to develop breast cancer had higher breast asymmetry than controls (absolute asymmetry odds ratio 1.50 per 100 ml, confidence interval (CI) 1.10, 2.04; relative asymmetry 1.09, CI 1.01, 1.18), increased incidence of family history of breast cancer, lower age at menarche, later menopause, later first pregnancies and a higher frequency of high risk breast parenchyma types. Conditional logistic regression analysis showed that breast asymmetry, height, family history of breast cancer, age at menarche, parenchyma type and menopausal status were significant independent predictors of breast cancer. When age at menopause was included in the model for the subgroup of post-menopausal women, absolute breast fluctuating asymmetry (FA) and relative breast FA remained significant effects. Breast asymmetry was greater in healthy women who later developed breast cancer than in women who did not.
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影响因子：
2.3
作者：
Mazzi, D;Künzler, R;Bakker, TCM
通讯作者：
Bakker, TCM
影响因子：
19.7
作者：
ANDERSSON, I;JANZON, L;PETTERSSON, H
通讯作者：
PETTERSSON, H
DOI：
10.1098/rspb.2001.1588
发表时间：
2001-05-07
影响因子：
4.7
作者：
Ditchkoff, SS;Lochmiller, RL;Leslie, DM
通讯作者：
Leslie, DM
DOI：
10.1098/rspb.1993.0012
发表时间：
1993-02-22
影响因子：
4.7
作者：
MANNING, JT;CHAMBERLAIN, AT
通讯作者：
CHAMBERLAIN, AT
DOI：
10.1098/rspb.2000.1137
发表时间：
2000-07-07
影响因子：
4.7
作者：
Martín, J;López, P
通讯作者：
López, P