CORRELATION BETWEEN PERIINFARCT DC SHIFTS AND ISCHEMIC NEURONAL DAMAGE IN RAT
CORRELATION BETWEEN PERIINFARCT DC SHIFTS AND ISCHEMIC NEURONAL DAMAGE IN RAT
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DOI：
10.1097/00001756-199306000-00027
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发表时间：
1993-06-01
期刊：
影响因子：
1.7
通讯作者：
HOSSMANN, KA
中科院分区：
文献类型：
--
作者：
MIES, G;IIJIMA, T;HOSSMANN, KA
在左大脑中动脉 (MCA) 闭塞 3 小时的大鼠中研究了梗死周围去极化对缺血性损伤的影响。去极化次数为 1 至 8 次，梗塞体积为 37 至 159 mm3。两个变量之间的相关性揭示了高度显着的线性关系（r = 0.800；p < 0.005），每次去极化导致梗塞体积增加约 13 mm3。随着去极化次数的增加，皮层直流漂移持续时间、脑电图振幅恢复时间和脑电图增量功率的逐渐增加也证明了重复去极化的加重效应。抑制梗塞周围去极化是降低缺血性中风严重程度的合理方法。
THE effect of peri-infarct depolarizations on ischaemic injury was studied in rats submitted to 3 h occlusion of the left middle cerebral artery (MCA). The number of depolarizations varied from 1 to 8 and infarct volume from 37 to 159 mm3. The correlation between the two variables revealed a highly significant linear relationship (r = 0.800; p < 0.005), each depolarization accounting for an increase in infarct volume by about 13 mm3. The aggravating effect of repeated depolarizations was also demonstrated by the gradual increase in cortical DC shift duration, in EEG amplitude recovery time, and in EEG delta power with increasing number of depolarizations. Suppression of peri-infarct depolarizations is a rational approach for reducing the severity of ischaemic stroke.