Mitochondrial bioenergetics as a major motive force of speciation
Mitochondrial bioenergetics as a major motive force of speciation
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DOI：
10.1002/bies.200800139
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发表时间：
2009-06-01
期刊：
影响因子：
4
通讯作者：
Mishmar, Dan
中科院分区：
文献类型：
--
作者：
Gershoni, Moran;Templeton, Alan R.;Mishmar, Dan
线粒体生物能量学在多种基本细胞过程中起着关键作用，如能量产生、核苷酸生物合成和铁代谢。它是动物生命和死亡（细胞凋亡）的基本系统，也是胚胎发育所必需的。这一点，结合其在多个物种中的适应过程及其基因产物参与动物生殖障碍的形成，提出了线粒体生物能量学可能是物种形成的候选遗传机制的可能性。在这里，我们讨论的遗传和生物化学证据可能参与这个独特的系统，编码的两个基因组（线粒体和核基因组），不同的数量级在其突变率的过程中导致物种形成事件。
Mitochondrial bioenergetics plays a key role in multiple basic cellular processes, such as energy production, nucleotide biosynthesis, and iron metabolism. It is an essential system for animals' life and death (apoptosis) and it is required for embryo development. This, in conjunction with its being subjected to adaptive processes in multiple species and its gene products being involved in the formation of reproductive barriers in animals, raises the possibility that mitochondrial bioenergetics could be a candidate genetic mechanism of speciation. Here, we discuss genetic and biochemical evidence for the possible involvement of this unique system, encoded by two genomes (the mitochondrial and nuclear genomes), that differ by an order of magnitude in their mutation rates in processes leading to speciation events.