IgG-effector functions: "The Good, The Bad and The Ugly"
IgG-effector functions: "The Good, The Bad and The Ugly"
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DOI：
10.1016/j.imlet.2014.01.015
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发表时间：
2014-08-01
影响因子：
4.4
通讯作者：
Vidarsson, Gestur
中科院分区：
文献类型：
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作者：
Kapur, Rick;Einarsdottir, Helga K.;Vidarsson, Gestur
IgG抗体是宿主保护的有效和通用介质。它们通过Fc部分与补体、特异性细胞受体或两者的特异性相互作用而引发其生物学效应。在分析通过IgG效应子功能引发的免疫应答的性质和强度时，应考虑几个因素，特别是对于仅在免疫细胞上表达的IgG-Fc受体（Fc γ R）家族。这些包括在不同免疫细胞上表达的各种类型的白细胞Fc γ R，每种对每个IgG亚类具有不同的亲和力，以及影响IgG表达和亲和力的遗传Fc γ R多态性。此外，IgG本身的各个方面对于生物反应的结果也是至关重要的。这些包括内源性编码的IgG多态性，如IgG 3多态性，和转录后IgG修饰，特别是IgG-Fc糖基化，通过改变与Fc γ R的结合亲和力影响IgG效应子功能。这些后者方面的可变性IgG 3的半衰期和胎盘运输和改变IgG质量通过糖基化的临床后果，将是本次审查的重点。(C)2014爱思唯尔有限公司版权所有。
IgG-antibodies are potent and versatile mediators of host protection. They elicit their biological effects through specific interaction of the Fc-part with complement, specific cellular receptors, or both. Several factors should be taken into consideration when analyzing the nature and intensity of the immunological response elicited via IgG-effector functions, especially for the family of IgG-Fc receptors (Fc gamma Rs) exclusively expressed on immune cells. These include the various classes of leukocyte Fc gamma R, expressed variably on different immune cells, each with distinct affinity for every IgG subclass, as well as genetic Fc gamma R-polymorphisms affecting expression and affinity for IgG. Furthermore, various aspects of the IgG itself are also crucial for the outcome of the biological response. These include endogenously encoded IgG-polymorphisms, such as IgG3 polymorphisms, and post-transcriptional IgG-modifications, in particular IgG-Fc-glycosylation, affecting IgG effector functions through modified binding affinity to Fc gamma R. These latter aspects concerning the variability in IgG3 on its half-life and placental transport and the clinical consequences of altered IgG-quality through glycosylation, will be the focus of this review. (C) 2014 Elsevier B.V. All rights reserved.