Validation of automatic bone age rating in children with precocious and early puberty
Validation of automatic bone age rating in children with precocious and early puberty
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DOI：
10.1515/jpem.2011.420
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发表时间：
2011-12-01
影响因子：
1.4
通讯作者：
Binder, Gerhard
中科院分区：
文献类型：
--
作者：
Martin, David D.;Meister, Kathrin;Binder, Gerhard
背景和目的：性早熟(PP)患者的手动骨龄(BA)评分与评分者的显著变异性有关。目的：评价儿童PP患者Greulich and Parle(GP)BA自动测定的新方法。方法：对13例PP或青春期早期各种原因(X线片时年龄0.3~14.8岁，平均BA进展2.3岁)的741名男孩和103名女孩的741张X线片进行评分。将自动评级(BoneXpert BA或BXBA)与原始手动GP评级(手动BA或Manba)进行比较。结果：除9张X线片(3张图像质量较差，6张X线片出自年龄小于1.5岁的儿童)外，其余741张X线片均自动分析。BXBA-MANBA的平均差值为-0.19岁，差值的SD为0.76年(95%可信区间为0.72~0.80)。确定了41幅图像的ReferenceBA。在与BXBA和MANBA对照的4幅图像和10幅图像中，参考BA的差异大于1.5年。结论：自动BA是治疗PP儿童的有效和可靠的方法。
Background and aims: Manual bone age (BA) rating in precocious puberty (PP) is associated with considerable rater variability. The aim was to evaluate a new method for automated Greulich and Pyle (GP) BA determination in children with PP.Methods: Seven hundred forty-one archived X-rays from 13 boys and 103 girls with PP or early puberty of various etiologies (age range at time of X-ray, 0.3-14.8 years; mean BA advancement, 2.3 years) were rated. Automatic rating (BoneXpert BA, or BXBA) was compared with the original manual GP rating (manual BA, or ManBA). X-rays where BXBA deviated from ManBA by more than 1.5 years were rerated by three raters, and the average was formed (ReferenceBA).Results: All 741 X-rays, except nine (three images had poor quality and six were from children with a chronological age younger than 1.5 years), were analyzed automatically. The mean difference of BXBA-ManBA was -0.19 years; the SD of the differences was 0.76 years (95% confidence interval 0.72-0.80). ReferenceBA was determined for 41 images. A discrepancy from ReferenceBA greater 1.5 years was found in four images against BXBA and in 10 images against ManBA.Conclusion: Automated BA is efficient and reliable in children with PP.