Extrinsic allergic alveolitis: incidence and mortality in the general population
Extrinsic allergic alveolitis: incidence and mortality in the general population
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DOI：
10.1093/qjmed/hcm008
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发表时间：
2007-04-01
影响因子：
13.3
通讯作者：
Hubbard, R.
中科院分区：
文献类型：
--
作者：
Solaymani-Dodaran, M.;West, J.;Hubbard, R.
背景资料：外源性过敏性肺泡炎（EAA）是一个重要的临床实体，但其发病率和意义在一般人群中是不确定的。目的：估计EAA的发病率，并导致死亡率，在英国。设计：一般人群为基础的队列研究在英国初级保健数据库（THIN）。方法：THIN患者与EAA的事件诊断进行了比较一般人群队列，其成员是4：按年龄、性别和全科医生执业情况配对。随访从首次诊断EAA时开始（匹配对照组在同一日期），并在死亡或随访结束时结束，以先发生者为准。泊松，逻辑，和考克斯比例风险回归模型;死亡率，比值比，和hazardratios进行了calculated.Results：我们确定了271例EAA事件（平均年龄在诊断57岁，51%男性）。在1991年至2003年期间，监管局的事故率稳定在每10万人年0.9例。与1084名普通人群对照组相比，EAA患者吸烟的可能性较小（比值比0.56，95%CI 0.39-0.81），但死亡风险显著增加（风险比2.98，95%C1 2.05-4.33）。讨论：EAA在英国人群中的发病率似乎随时间推移而稳定，并表明每年约有600例EAA新发病例。患有EAA的人比一般人群吸烟的可能性更小，但死亡率明显增加。
Background: Extrinsic allergic alveolitis (EAA) is an important clinical entity, but its incidence and significance in the general population are uncertain.Aim: To estimate the incidence of EAA, and resulting mortality, in the UK.Design: General-population-based cohort study in a UK primary care database (THIN).Methods: THIN patients with an incident diagnosis of EAA were compared with a general population cohort whose members were 4:1 matched with EAA patients by age, sex and GP practice. Follow-up started at the first diagnosis of EAA (and at the same date in the matched controls) and ended at death or end of follow-up, whichever came first. Poisson, logistic, and Cox proportional hazard regression models were used; mortality rate, odd ratios, and hazard ratios were calculated.Results: We identified 271 incident cases of EAA (mean age at diagnosis 57 years, 51% male). Between 1991 and 2003, the incident rate for EAA was stable at similar to 0.9 cases per 100000 person-years. In comparison to the 1084 general population controls, patients with EAA were less likely to smoke (odds ratio 0.56, 95%Cl 0.39-0.81), but had a marked increase in the risk of death (hazard ratio 2.98, 95%C1 2.05-4.33).Discussion: The incidence of EAA in the UK population appears to be stable overtime, and suggests about 600 new cases of EAA each year. People with EAA are less likely to smoke than the general population, but have a markedly increased mortality rate.