Protein fouling resistant membrane prepared by amphiphilic pegylated polyethersulfone
Protein fouling resistant membrane prepared by amphiphilic pegylated polyethersulfone
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DOI：
10.1016/j.biortech.2010.10.045
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发表时间：
2011-02-01
影响因子：
11.4
通讯作者：
Jiang, Zhongyi
中科院分区：
文献类型：
--
作者：
Peng, Jinming;Su, Yanlei;Jiang, Zhongyi
以聚醚砜（PES）为单体，采用温和、简便的接枝方法合成了聚醚二醇甲基醚甲基丙烯酸酯（PEGMA）单体。然后，通过非溶剂诱导相转化和表面分离的耦合，制备了具有整体各向异性形貌的PES-g-PEGMA膜。与PES对照膜相比，PES-g-PEGMA膜表面聚乙二醇（PEG）链段的大量富集使膜表面亲水性显著增强，亲水基团与水分子之间的氢键作用使蛋白质吸附受到明显抑制。超滤实验用于评估PES-g-PEGMA膜的渗透性和抗蛋白质污染性。结果表明，PEG链段表面覆盖率越高，PES-g-PEGMA膜的抗生物污染能力越强。PES-g-PEGMA膜的抗生物污染性能是由于亲水性PEGMA侧链与PES主链之间的共价键相互作用而获得的。(C)2010爱思唯尔有限公司版权所有。
A mild and facile grafting of poly(ether glycol) methyl ether methacrylate (PEGMA) monomers onto polyethersulfone (PES) was carried out. Then, the PES-g-PEGMA membranes with integrally anisotropic morphology were fabricated through the coupling of non-solvent induced phase inversion and surface segregation. Compared with PES control membrane, the surface hydrophilicity of PES-g-PEGMA membranes was remarkably enhanced due to the drastic enrichment of poly(ethylene glycol) (PEG) segments on the membrane surface; protein adsorption was significantly inhibited due to the hydrogen bonding interactions between hydrophilic groups and water molecules. Ultrafiltration experiments were used to assess the permeability and protein fouling resistance of the PES-g-PEGMA membranes. It was found that the PES-g-PEGMA membranes with higher surface coverage of PEG segments displayed stronger antibiofouling property. Moreover, the stable antibiofouling property for PES-g-PEGMA membranes was acquired due to covalent bonding interactions between hydrophilic PEGMA side chains and PES main chains. (C) 2010 Elsevier Ltd. All rights reserved.