Axon Pruning and Synaptic Development: How Are They per-Plexin?
Axon Pruning and Synaptic Development: How Are They per-Plexin?
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DOI：
10.1177/1073858406292631
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发表时间：
2006-10
期刊：
影响因子：
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通讯作者：
K. E. Waimey;Hwai-Jong Cheng
中科院分区：
文献类型：
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作者：
K. E. Waimey;Hwai-Jong Cheng
在神经系统的发育过程中，神经元必须首先迁移到适当的位置，然后发出轴突进行连接。各种环境线索引导这些迁移的神经元和生长的轴突。在轴突到达它们的目标区域之后，通过突触的形成来创建神经元接触。因为过多的轴突分支和突触接触通常在早期发育过程中形成，所以它们在后期阶段被修剪或消除以产生特定的神经元连接。已经鉴定了几组配体-受体对来调节这些细胞事件中的每一个。证据还表明，这些相同的分子可能用于多种发育过程。在这里，我们讨论了信号蛋白和丛蛋白，轴突导向配体受体对的最大的家庭。由于脑信号蛋白在神经元迁移和轴突排斥中的作用已被广泛综述，我们将重点放在丛蛋白受体上。我们将讨论如何semaphorin信号是专门通过这些受体进入细胞，以及如何plexins介导轴突修剪和突触发育的新发现的作用。
During the development of the nervous system, neurons must first migrate to their appropriate locations and then send out axons to make connections. Various environmental cues guide these migrating neurons and growing axons. After axons reach their target regions, neuronal contacts are created through the formation of synapses. Because excess axonal branches and synaptic contacts are often formed during early development, they are pruned or eliminated at later stages to create specific neuronal connections. Several groups of ligand-receptor pairs have been identified to regulate each of these cellular events. Evidence also indicates that these same molecules may be used in multiple developmental processes. Here, we discuss semaphorins and plexins, the largest family of axon guidance ligand-receptor pairs. Because the roles of semaphorins in neuronal migration and axonal repulsion have been extensively reviewed, we will focus on plexin receptors. We will discuss how semaphorin signals are specifically passed through these receptors into cells and how plexins mediate their newly identified roles in axon pruning and synaptic development.