Age-related changes of vasopressin content of microdissected areas of the rat brain
Age-related changes of vasopressin content of microdissected areas of the rat brain
复制标题
大鼠大脑显微解剖区域加压素含量与年龄相关的变化
DOI：
10.1016/0006-8993(82)90505-4
复制
发表时间：
1982
期刊：
影响因子：
2.9
通讯作者：
Lucy A. Bottemiller
中科院分区：
文献类型：
--
作者：
D. Dorsa;Lucy A. Bottemiller
用放射免疫法测定了3月龄和24月龄Long-Evans大鼠和Brattleboro大鼠尿崩症杂合子(Hedi)和纯合子(Hodi)大鼠脑垂体后叶和下丘脑内外核中加压素的含量。在荷迪脑下垂体中没有检测到这种多肽。与年轻动物相比，在所研究的大脑区域，老年和河迪大鼠的加压素含量都有所降低。根据Hedi和Hodi大鼠记忆缺陷的证据，与衰老相关的记忆减退可能与这些神经系统老化时发生的加压素合成和/或分泌改变有关。
Vasopressin contents of posterior pituitaries and intra- and extrahypothalamic nuclei of brains from 3-month and 24-month-old Long-Evans rats and from Brattleboro rats heterozygous (HEDI) and homozygous (HODI) for diabetes insipidus were measured by radioimmunoassay.The pituitary content of vasopressin was highest in young rats and was significantly lower in HEDI tissue. The peptide was not detected in HODI pituitaries.In the brain regions studied both aged and HEDI rats showed reduced vasopressin contents as compared to young animals. In light of evidence of memory deficiencies in both HEDI and HODI rats, the possibility arises that memory decrements associated with senescence may be related to altered vasopressin synthesis and/or secretion occurring with aging of these neuronal systems.